Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes

Histone posttranslational modifications are key regulators of chromatin-associated processes including gene expression, DNA replication and DNA repair. Monoubiquitinated histone H2A, H2Aub (K118 in Drosophila or K119 in vertebrates) is catalyzed by the Polycomb group (PcG) repressive complex 1 (PRC1...

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Autores principales: Barbour, Haithem, Daou, Salima, Hendzel, Michael, Affar, El Bachir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683540/
https://www.ncbi.nlm.nih.gov/pubmed/33230107
http://dx.doi.org/10.1038/s41467-020-19722-9
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author Barbour, Haithem
Daou, Salima
Hendzel, Michael
Affar, El Bachir
author_facet Barbour, Haithem
Daou, Salima
Hendzel, Michael
Affar, El Bachir
author_sort Barbour, Haithem
collection PubMed
description Histone posttranslational modifications are key regulators of chromatin-associated processes including gene expression, DNA replication and DNA repair. Monoubiquitinated histone H2A, H2Aub (K118 in Drosophila or K119 in vertebrates) is catalyzed by the Polycomb group (PcG) repressive complex 1 (PRC1) and reversed by the PcG-repressive deubiquitinase (PR-DUB)/BAP1 complex. Here we critically assess the current knowledge regarding H2Aub deposition and removal, its crosstalk with PcG repressive complex 2 (PRC2)-mediated histone H3K27 methylation, and the recent attempts toward discovering its readers and solving its enigmatic functions. We also discuss mounting evidence of the involvement of H2A ubiquitination in human pathologies including cancer, while highlighting some knowledge gaps that remain to be addressed.
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spelling pubmed-76835402020-12-03 Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes Barbour, Haithem Daou, Salima Hendzel, Michael Affar, El Bachir Nat Commun Review Article Histone posttranslational modifications are key regulators of chromatin-associated processes including gene expression, DNA replication and DNA repair. Monoubiquitinated histone H2A, H2Aub (K118 in Drosophila or K119 in vertebrates) is catalyzed by the Polycomb group (PcG) repressive complex 1 (PRC1) and reversed by the PcG-repressive deubiquitinase (PR-DUB)/BAP1 complex. Here we critically assess the current knowledge regarding H2Aub deposition and removal, its crosstalk with PcG repressive complex 2 (PRC2)-mediated histone H3K27 methylation, and the recent attempts toward discovering its readers and solving its enigmatic functions. We also discuss mounting evidence of the involvement of H2A ubiquitination in human pathologies including cancer, while highlighting some knowledge gaps that remain to be addressed. Nature Publishing Group UK 2020-11-23 /pmc/articles/PMC7683540/ /pubmed/33230107 http://dx.doi.org/10.1038/s41467-020-19722-9 Text en © Crown 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Barbour, Haithem
Daou, Salima
Hendzel, Michael
Affar, El Bachir
Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
title Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
title_full Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
title_fullStr Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
title_full_unstemmed Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
title_short Polycomb group-mediated histone H2A monoubiquitination in epigenome regulation and nuclear processes
title_sort polycomb group-mediated histone h2a monoubiquitination in epigenome regulation and nuclear processes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683540/
https://www.ncbi.nlm.nih.gov/pubmed/33230107
http://dx.doi.org/10.1038/s41467-020-19722-9
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