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hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese
BACKGROUND: The Ser326Cys polymorphism in human oxoguanine glycosylase 1 (hOGG1), which is involved in the repair of 8-hydroxy-2-deoxyguanine in oxidatively damaged DNA, has been associated with susceptibility to certain cancers, but has not been examined in causation of hepatocellular carcinoma (HC...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japan Epidemiological Association
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683698/ https://www.ncbi.nlm.nih.gov/pubmed/17085873 http://dx.doi.org/10.2188/jea.16.233 |
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author | Sakamoto, Tatsuhiko Higaki, Yasuki Hara, Megumi Ichiba, Masayoshi Horita, Mikako Mizuta, Toshihiko Eguchi, Yuichiro Yasutake, Tsutomu Ozaki, Iwata Yamamoto, Kyosuke Onohara, Shingo Kawazoe, Seiji Shigematsu, Hirohisa Koizumi, Shunzo Tanaka, Keitaro |
author_facet | Sakamoto, Tatsuhiko Higaki, Yasuki Hara, Megumi Ichiba, Masayoshi Horita, Mikako Mizuta, Toshihiko Eguchi, Yuichiro Yasutake, Tsutomu Ozaki, Iwata Yamamoto, Kyosuke Onohara, Shingo Kawazoe, Seiji Shigematsu, Hirohisa Koizumi, Shunzo Tanaka, Keitaro |
author_sort | Sakamoto, Tatsuhiko |
collection | PubMed |
description | BACKGROUND: The Ser326Cys polymorphism in human oxoguanine glycosylase 1 (hOGG1), which is involved in the repair of 8-hydroxy-2-deoxyguanine in oxidatively damaged DNA, has been associated with susceptibility to certain cancers, but has not been examined in causation of hepatocellular carcinoma (HCC). METHODS: We conducted a case-control study to investigate whether this polymorphism was related to HCC risk with any interaction with alcohol consumption and cigarette smoking. Genotyping was performed by a polymerase chain reaction with confronting two-pair primers among 209 newly diagnosed HCC cases, 275 hospital controls, and 381 patients with chronic liver disease (CLD) without HCC. RESULTS: Overall, the hOGG1 genotype was not significantly associated with HCC; adjusted odds ratios (and 95% confidence intervals) for the Ser/Cys and Cys/Cys genotypes compared with the Ser/Ser genotype were 0.79 (0.35-1.79) and 0.48 (0.18-1.27) against hospital controls, and 1.51 (0.96-3.37) and 0.86 (0.50-1.47) against CLD patients. We could not detect any significant gene-alcohol interaction (p = 0.95 or 0.16) or gene-smoking interaction (p = 0.70 or 0.69). CONCLUTIONS: These results suggest that the hOGG1 Ser326Cys polymorphism may not play a major role as an independent factor in hepatocarcinogenesis. |
format | Online Article Text |
id | pubmed-7683698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Japan Epidemiological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-76836982020-12-04 hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese Sakamoto, Tatsuhiko Higaki, Yasuki Hara, Megumi Ichiba, Masayoshi Horita, Mikako Mizuta, Toshihiko Eguchi, Yuichiro Yasutake, Tsutomu Ozaki, Iwata Yamamoto, Kyosuke Onohara, Shingo Kawazoe, Seiji Shigematsu, Hirohisa Koizumi, Shunzo Tanaka, Keitaro J Epidemiol Original Article BACKGROUND: The Ser326Cys polymorphism in human oxoguanine glycosylase 1 (hOGG1), which is involved in the repair of 8-hydroxy-2-deoxyguanine in oxidatively damaged DNA, has been associated with susceptibility to certain cancers, but has not been examined in causation of hepatocellular carcinoma (HCC). METHODS: We conducted a case-control study to investigate whether this polymorphism was related to HCC risk with any interaction with alcohol consumption and cigarette smoking. Genotyping was performed by a polymerase chain reaction with confronting two-pair primers among 209 newly diagnosed HCC cases, 275 hospital controls, and 381 patients with chronic liver disease (CLD) without HCC. RESULTS: Overall, the hOGG1 genotype was not significantly associated with HCC; adjusted odds ratios (and 95% confidence intervals) for the Ser/Cys and Cys/Cys genotypes compared with the Ser/Ser genotype were 0.79 (0.35-1.79) and 0.48 (0.18-1.27) against hospital controls, and 1.51 (0.96-3.37) and 0.86 (0.50-1.47) against CLD patients. We could not detect any significant gene-alcohol interaction (p = 0.95 or 0.16) or gene-smoking interaction (p = 0.70 or 0.69). CONCLUTIONS: These results suggest that the hOGG1 Ser326Cys polymorphism may not play a major role as an independent factor in hepatocarcinogenesis. Japan Epidemiological Association 2006-11-03 /pmc/articles/PMC7683698/ /pubmed/17085873 http://dx.doi.org/10.2188/jea.16.233 Text en © 2006 Japan Epidemiological Association. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article Sakamoto, Tatsuhiko Higaki, Yasuki Hara, Megumi Ichiba, Masayoshi Horita, Mikako Mizuta, Toshihiko Eguchi, Yuichiro Yasutake, Tsutomu Ozaki, Iwata Yamamoto, Kyosuke Onohara, Shingo Kawazoe, Seiji Shigematsu, Hirohisa Koizumi, Shunzo Tanaka, Keitaro hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese |
title | hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese |
title_full | hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese |
title_fullStr | hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese |
title_full_unstemmed | hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese |
title_short | hOGG1 Ser326Cys Polymorphism and Risk of Hepatocellular Carcinoma among Japanese |
title_sort | hogg1 ser326cys polymorphism and risk of hepatocellular carcinoma among japanese |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683698/ https://www.ncbi.nlm.nih.gov/pubmed/17085873 http://dx.doi.org/10.2188/jea.16.233 |
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