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Moving Beyond the Pillars of Cancer Treatment: Perspectives From Nanotechnology
Nanotechnology has made a significant impact on basic and clinical cancer research over the past two decades. Owing to multidisciplinary advances, cancer nanotechnology aims to address the problems in current cancer treatment paradigms, with the ultimate goal to improve treatment efficacy, increase...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683771/ https://www.ncbi.nlm.nih.gov/pubmed/33240859 http://dx.doi.org/10.3389/fchem.2020.598100 |
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author | Siamof, Cerise M. Goel, Shreya Cai, Weibo |
author_facet | Siamof, Cerise M. Goel, Shreya Cai, Weibo |
author_sort | Siamof, Cerise M. |
collection | PubMed |
description | Nanotechnology has made a significant impact on basic and clinical cancer research over the past two decades. Owing to multidisciplinary advances, cancer nanotechnology aims to address the problems in current cancer treatment paradigms, with the ultimate goal to improve treatment efficacy, increase patient survival, and decrease toxic side-effects. The potential for use of nanomedicine in cancer targeting and therapy has grown, and is now used to advance the four traditional pillars of cancer treatment: surgery, chemotherapy, radiation therapy and the newest pillar, immunotherapy. In this review we provide an overview of notable advances of nanomedicine in improving drug delivery, radiation therapy and immunotherapy. Potential barriers in the translation of nanomedicine from bench to bedside as well as strategies to overcome these barriers are also discussed. Promising preclinical findings highlight the translational and clinical potential of integrating nanotechnology approaches into cancer care. |
format | Online Article Text |
id | pubmed-7683771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76837712020-11-24 Moving Beyond the Pillars of Cancer Treatment: Perspectives From Nanotechnology Siamof, Cerise M. Goel, Shreya Cai, Weibo Front Chem Chemistry Nanotechnology has made a significant impact on basic and clinical cancer research over the past two decades. Owing to multidisciplinary advances, cancer nanotechnology aims to address the problems in current cancer treatment paradigms, with the ultimate goal to improve treatment efficacy, increase patient survival, and decrease toxic side-effects. The potential for use of nanomedicine in cancer targeting and therapy has grown, and is now used to advance the four traditional pillars of cancer treatment: surgery, chemotherapy, radiation therapy and the newest pillar, immunotherapy. In this review we provide an overview of notable advances of nanomedicine in improving drug delivery, radiation therapy and immunotherapy. Potential barriers in the translation of nanomedicine from bench to bedside as well as strategies to overcome these barriers are also discussed. Promising preclinical findings highlight the translational and clinical potential of integrating nanotechnology approaches into cancer care. Frontiers Media S.A. 2020-11-10 /pmc/articles/PMC7683771/ /pubmed/33240859 http://dx.doi.org/10.3389/fchem.2020.598100 Text en Copyright © 2020 Siamof, Goel and Cai. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Siamof, Cerise M. Goel, Shreya Cai, Weibo Moving Beyond the Pillars of Cancer Treatment: Perspectives From Nanotechnology |
title | Moving Beyond the Pillars of Cancer Treatment: Perspectives From Nanotechnology |
title_full | Moving Beyond the Pillars of Cancer Treatment: Perspectives From Nanotechnology |
title_fullStr | Moving Beyond the Pillars of Cancer Treatment: Perspectives From Nanotechnology |
title_full_unstemmed | Moving Beyond the Pillars of Cancer Treatment: Perspectives From Nanotechnology |
title_short | Moving Beyond the Pillars of Cancer Treatment: Perspectives From Nanotechnology |
title_sort | moving beyond the pillars of cancer treatment: perspectives from nanotechnology |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683771/ https://www.ncbi.nlm.nih.gov/pubmed/33240859 http://dx.doi.org/10.3389/fchem.2020.598100 |
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