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PCSK9 Gene E670G Polymorphism and Coronary Artery Disease: An Updated Meta-Analysis of 5,484 Subjects

Objective: Research has shown a possible relationship between the E670G polymorphism of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene and an increased risk of coronary artery disease (CAD). However, there is no clear consensus on the subject because of conflicting results in the lit...

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Detalles Bibliográficos
Autores principales: Li, Yan-yan, Wang, Hui, Yang, Xin-xing, Geng, Hong-yu, Gong, Ge, Lu, Xin-zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683799/
https://www.ncbi.nlm.nih.gov/pubmed/33244470
http://dx.doi.org/10.3389/fcvm.2020.582865
Descripción
Sumario:Objective: Research has shown a possible relationship between the E670G polymorphism of the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene and an increased risk of coronary artery disease (CAD). However, there is no clear consensus on the subject because of conflicting results in the literature. The current meta-analysis was performed to better elucidate the potential relationship between the PCSK9 gene E670G polymorphism and CAD. Methods: There were 5,484 subjects from 13 individual studies who were included in the current meta-analysis. The fixed- or random-effects models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). Results: The current meta-analysis found a significant association between PCSK9 gene E670G polymorphism and CAD under allelic (OR = 1.79, 95% CI = 1.42–2.27, P = 1.00 × 10(−6)), dominant (OR = 2.16, 95% CI = 1.61–2.89, P = 2.22 × 10(−7)), heterozygous (OR = 2.02, 95% CI = 1.55–2.64, P = 2.47 × 10(−7)), and additive genetic models (OR = 1.92, 95% CI = 1.49–2.49, P = 6.70 × 10(−7)). Conclusions: PCSK9 gene E670G polymorphism was associated with an elevated risk of CAD, especially in the Chinese population. More specifically, carriers of the G allele carriers of the PCSK9 gene may be predisposed to developing CAD.