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Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD

Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly. Despite recent advances in our understanding of the basic biological mechanisms underlying AD, we do not know how to prevent it, nor do we have an approved disease‐modifying intervention. Both are essen...

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Autores principales: Oblak, Adrian L., Forner, Stefania, Territo, Paul R., Sasner, Michael, Carter, Gregory W., Howell, Gareth R., Sukoff‐Rizzo, Stacey J., Logsdon, Benjamin A., Mangravite, Lara M., Mortazavi, Ali, Baglietto‐Vargas, David, Green, Kim N., MacGregor, Grant R., Wood, Marcelo A., Tenner, Andrea J., LaFerla, Frank M., Lamb, Bruce T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683958/
https://www.ncbi.nlm.nih.gov/pubmed/33283040
http://dx.doi.org/10.1002/trc2.12110
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author Oblak, Adrian L.
Forner, Stefania
Territo, Paul R.
Sasner, Michael
Carter, Gregory W.
Howell, Gareth R.
Sukoff‐Rizzo, Stacey J.
Logsdon, Benjamin A.
Mangravite, Lara M.
Mortazavi, Ali
Baglietto‐Vargas, David
Green, Kim N.
MacGregor, Grant R.
Wood, Marcelo A.
Tenner, Andrea J.
LaFerla, Frank M.
Lamb, Bruce T.
author_facet Oblak, Adrian L.
Forner, Stefania
Territo, Paul R.
Sasner, Michael
Carter, Gregory W.
Howell, Gareth R.
Sukoff‐Rizzo, Stacey J.
Logsdon, Benjamin A.
Mangravite, Lara M.
Mortazavi, Ali
Baglietto‐Vargas, David
Green, Kim N.
MacGregor, Grant R.
Wood, Marcelo A.
Tenner, Andrea J.
LaFerla, Frank M.
Lamb, Bruce T.
author_sort Oblak, Adrian L.
collection PubMed
description Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly. Despite recent advances in our understanding of the basic biological mechanisms underlying AD, we do not know how to prevent it, nor do we have an approved disease‐modifying intervention. Both are essential to slow or stop the growth in dementia prevalence. While our current animal models of AD have provided novel insights into AD disease mechanisms, thus far, they have not been successfully used to predict the effectiveness of therapies that have moved into AD clinical trials. The Model Organism Development and Evaluation for Late‐onset Alzheimer's Disease (MODEL‐AD; www.model-ad.org) Consortium was established to maximize human datasets to identify putative variants, genes, and biomarkers for AD; to generate, characterize, and validate the next generation of mouse models of AD; and to develop a preclinical testing pipeline. MODEL‐AD is a collaboration among Indiana University (IU); The Jackson Laboratory (JAX); University of Pittsburgh School of Medicine (Pitt); Sage BioNetworks (Sage); and the University of California, Irvine (UCI) that will generate new AD modeling processes and pipelines, data resources, research results, standardized protocols, and models that will be shared through JAX's and Sage's proven dissemination pipelines with the National Institute on Aging–supported AD Centers, academic and medical research centers, research institutions, and the pharmaceutical industry worldwide.
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spelling pubmed-76839582020-12-03 Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD Oblak, Adrian L. Forner, Stefania Territo, Paul R. Sasner, Michael Carter, Gregory W. Howell, Gareth R. Sukoff‐Rizzo, Stacey J. Logsdon, Benjamin A. Mangravite, Lara M. Mortazavi, Ali Baglietto‐Vargas, David Green, Kim N. MacGregor, Grant R. Wood, Marcelo A. Tenner, Andrea J. LaFerla, Frank M. Lamb, Bruce T. Alzheimers Dement (N Y) Perspective Alzheimer's disease (AD) is a major cause of dementia, disability, and death in the elderly. Despite recent advances in our understanding of the basic biological mechanisms underlying AD, we do not know how to prevent it, nor do we have an approved disease‐modifying intervention. Both are essential to slow or stop the growth in dementia prevalence. While our current animal models of AD have provided novel insights into AD disease mechanisms, thus far, they have not been successfully used to predict the effectiveness of therapies that have moved into AD clinical trials. The Model Organism Development and Evaluation for Late‐onset Alzheimer's Disease (MODEL‐AD; www.model-ad.org) Consortium was established to maximize human datasets to identify putative variants, genes, and biomarkers for AD; to generate, characterize, and validate the next generation of mouse models of AD; and to develop a preclinical testing pipeline. MODEL‐AD is a collaboration among Indiana University (IU); The Jackson Laboratory (JAX); University of Pittsburgh School of Medicine (Pitt); Sage BioNetworks (Sage); and the University of California, Irvine (UCI) that will generate new AD modeling processes and pipelines, data resources, research results, standardized protocols, and models that will be shared through JAX's and Sage's proven dissemination pipelines with the National Institute on Aging–supported AD Centers, academic and medical research centers, research institutions, and the pharmaceutical industry worldwide. John Wiley and Sons Inc. 2020-11-23 /pmc/articles/PMC7683958/ /pubmed/33283040 http://dx.doi.org/10.1002/trc2.12110 Text en © 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Perspective
Oblak, Adrian L.
Forner, Stefania
Territo, Paul R.
Sasner, Michael
Carter, Gregory W.
Howell, Gareth R.
Sukoff‐Rizzo, Stacey J.
Logsdon, Benjamin A.
Mangravite, Lara M.
Mortazavi, Ali
Baglietto‐Vargas, David
Green, Kim N.
MacGregor, Grant R.
Wood, Marcelo A.
Tenner, Andrea J.
LaFerla, Frank M.
Lamb, Bruce T.
Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD
title Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD
title_full Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD
title_fullStr Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD
title_full_unstemmed Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD
title_short Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD
title_sort model organism development and evaluation for late‐onset alzheimer's disease: model‐ad
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683958/
https://www.ncbi.nlm.nih.gov/pubmed/33283040
http://dx.doi.org/10.1002/trc2.12110
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