Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Severe cases of COVID-19 are characterized by a strong inflammatory process that may ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular platform that promotes inflammation via cleavage and activation of key inflammatory molecules including active caspase-1 (Cas...

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Detalles Bibliográficos
Autores principales: Rodrigues, Tamara S., de Sá, Keyla S.G., Ishimoto, Adriene Y., Becerra, Amanda, Oliveira, Samuel, Almeida, Leticia, Gonçalves, Augusto V., Perucello, Debora B., Andrade, Warrison A., Castro, Ricardo, Veras, Flavio P., Toller-Kawahisa, Juliana E., Nascimento, Daniele C., de Lima, Mikhael H.F., Silva, Camila M.S., Caetite, Diego B., Martins, Ronaldo B., Castro, Italo A., Pontelli, Marjorie C., de Barros, Fabio C., do Amaral, Natália B., Giannini, Marcela C., Bonjorno, Letícia P., Lopes, Maria Isabel F., Santana, Rodrigo C., Vilar, Fernando C., Auxiliadora-Martins, Maria, Luppino-Assad, Rodrigo, de Almeida, Sergio C.L., de Oliveira, Fabiola R., Batah, Sabrina S., Siyuan, Li, Benatti, Maira N., Cunha, Thiago M., Alves-Filho, José C., Cunha, Fernando Q., Cunha, Larissa D., Frantz, Fabiani G., Kohlsdorf, Tiana, Fabro, Alexandre T., Arruda, Eurico, de Oliveira, Renê D.R., Louzada-Junior, Paulo, Zamboni, Dario S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684031/
https://www.ncbi.nlm.nih.gov/pubmed/33231615
http://dx.doi.org/10.1084/jem.20201707

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