ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine

Recurrent somatic mutations in ETNK1 (Ethanolamine-Kinase-1) were identified in several myeloid malignancies and are responsible for a reduced enzymatic activity. Here, we demonstrate in primary leukemic cells and in cell lines that mutated ETNK1 causes a significant increase in mitochondrial activi...

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Detalles Bibliográficos
Autores principales: Fontana, Diletta, Mauri, Mario, Renso, Rossella, Docci, Mattia, Crespiatico, Ilaria, Røst, Lisa M., Jang, Mi, Niro, Antonio, D’Aliberti, Deborah, Massimino, Luca, Bertagna, Mayla, Zambrotta, Giovanni, Bossi, Mario, Citterio, Stefania, Crescenzi, Barbara, Fanelli, Francesca, Cassina, Valeria, Corti, Roberta, Salerno, Domenico, Nardo, Luca, Chinello, Clizia, Mantegazza, Francesco, Mecucci, Cristina, Magni, Fulvio, Cavaletti, Guido, Bruheim, Per, Rea, Delphine, Larsen, Steen, Gambacorti-Passerini, Carlo, Piazza, Rocco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684297/
https://www.ncbi.nlm.nih.gov/pubmed/33230096
http://dx.doi.org/10.1038/s41467-020-19721-w

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