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Gastric acid level of humans must decrease in the future

Proton pump inhibitors strongly inhibit gastric acid production, but digestion problems do not generally arise. We can intake almost ordinary food even after total gastrectomy. Small intestine itself can digest and absorb food using various digestive enzymes without digestion in the stomach. The pH...

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Autor principal: Fujimori, Shunji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684463/
https://www.ncbi.nlm.nih.gov/pubmed/33268958
http://dx.doi.org/10.3748/wjg.v26.i43.6706
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author Fujimori, Shunji
author_facet Fujimori, Shunji
author_sort Fujimori, Shunji
collection PubMed
description Proton pump inhibitors strongly inhibit gastric acid production, but digestion problems do not generally arise. We can intake almost ordinary food even after total gastrectomy. Small intestine itself can digest and absorb food using various digestive enzymes without digestion in the stomach. The pH level of gastric acid in humans is much lower than that of most animals, and very close to that of carrion-eating animals called scavengers. It is assumed that ancient humans became bipedal approximately 4 million years ago. It was difficult for humans, who just started unstable bipedal locomotion, to catch quadrupedal-walking animals that can move faster, without special hunting tools. They may have eaten remaining carcasses, which is mainly the leftovers of carnivora species, as animal-derived food. The benefit to produce a volume of gastric acid for humans is carrion eating, in which disinfection by gastric acid is important. Humans produce a high concentration of gastric acid to enable consumption of a diet containing some bacteria and support this lifestyle by consuming significant energy to protect themselves from gastric acid. Now, the opportunity for strong deleterious bacteria to enter the gastrointestinal tract has decreased because of the organized clean environment. If this hygienic environment is maintained for a long time, our gastric acid level must be decreased gradually.
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spelling pubmed-76844632020-12-01 Gastric acid level of humans must decrease in the future Fujimori, Shunji World J Gastroenterol Opinion Review Proton pump inhibitors strongly inhibit gastric acid production, but digestion problems do not generally arise. We can intake almost ordinary food even after total gastrectomy. Small intestine itself can digest and absorb food using various digestive enzymes without digestion in the stomach. The pH level of gastric acid in humans is much lower than that of most animals, and very close to that of carrion-eating animals called scavengers. It is assumed that ancient humans became bipedal approximately 4 million years ago. It was difficult for humans, who just started unstable bipedal locomotion, to catch quadrupedal-walking animals that can move faster, without special hunting tools. They may have eaten remaining carcasses, which is mainly the leftovers of carnivora species, as animal-derived food. The benefit to produce a volume of gastric acid for humans is carrion eating, in which disinfection by gastric acid is important. Humans produce a high concentration of gastric acid to enable consumption of a diet containing some bacteria and support this lifestyle by consuming significant energy to protect themselves from gastric acid. Now, the opportunity for strong deleterious bacteria to enter the gastrointestinal tract has decreased because of the organized clean environment. If this hygienic environment is maintained for a long time, our gastric acid level must be decreased gradually. Baishideng Publishing Group Inc 2020-11-21 2020-11-21 /pmc/articles/PMC7684463/ /pubmed/33268958 http://dx.doi.org/10.3748/wjg.v26.i43.6706 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Opinion Review
Fujimori, Shunji
Gastric acid level of humans must decrease in the future
title Gastric acid level of humans must decrease in the future
title_full Gastric acid level of humans must decrease in the future
title_fullStr Gastric acid level of humans must decrease in the future
title_full_unstemmed Gastric acid level of humans must decrease in the future
title_short Gastric acid level of humans must decrease in the future
title_sort gastric acid level of humans must decrease in the future
topic Opinion Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684463/
https://www.ncbi.nlm.nih.gov/pubmed/33268958
http://dx.doi.org/10.3748/wjg.v26.i43.6706
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