Four Phosphates at One Blow: Access to Pentaphosphorylated Magic Spot Nucleotides and Their Analysis by Capillary Electrophoresis

[Image: see text] The complex phosphorylation pattern of natural and modified pentaphosphorylated magic spot nucleotides is generated in a highly efficient way. A cyclic pyrophosphoryl phosphoramidite (cPyPA) reagent is used to introduce four phosphates on nucleosides regioselectively in a one-flask...

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Detalles Bibliográficos
Autores principales: Haas, Thomas M., Qiu, Danye, Häner, Markus, Angebauer, Larissa, Ripp, Alexander, Singh, Jyoti, Koch, Hans-Georg, Jessen-Trefzer, Claudia, Jessen, Henning J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684580/
https://www.ncbi.nlm.nih.gov/pubmed/32502348
http://dx.doi.org/10.1021/acs.joc.0c00841

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