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Synthesis and investigation of quadruplex-DNA-binding, 9-O-substituted berberine derivatives

A small series of five novel berberine derivatives was synthesized by the Cu-catalyzed click reaction of 9-propargyladenine with 9-O-(azidoalkyl)berberine derivatives. The association of the resulting berberine–adenine conjugates with representative quadruplex-forming oligonucleotides 22AG dA(G(3)TT...

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Detalles Bibliográficos
Autores principales:	Becher, Jonas, Berdnikova, Daria V, Ihmels, Heiko, Stremmel, Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2020
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684686/ https://www.ncbi.nlm.nih.gov/pubmed/33281983 http://dx.doi.org/10.3762/bjoc.16.230

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