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Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes
Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the nuclear DNA. As such, variations in nuclear gene expression as a consequence of mutations and epigenetic modifications can affect mitochondrial functionality. Conversely, the opposite could also be true. Howeve...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684747/ https://www.ncbi.nlm.nih.gov/pubmed/33228792 http://dx.doi.org/10.1186/s13148-020-00976-5 |
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author | F. C. Lopes, Amanda |
author_facet | F. C. Lopes, Amanda |
author_sort | F. C. Lopes, Amanda |
collection | PubMed |
description | Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the nuclear DNA. As such, variations in nuclear gene expression as a consequence of mutations and epigenetic modifications can affect mitochondrial functionality. Conversely, the opposite could also be true. However, the relationship between mitochondrial dysfunction and epigenetics, such as nuclear DNA methylation, remains largely unexplored. Mitochondria function as central metabolic hubs controlling some of the main substrates involved in nuclear DNA methylation, via the one carbon metabolism, the tricarboxylic acid cycle and the methionine pathway. Here, we review key findings and highlight new areas of focus, with the ultimate goal of getting one step closer to understanding the genomic effects of mitochondrial dysfunction on nuclear epigenetic landscapes. |
format | Online Article Text |
id | pubmed-7684747 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76847472020-11-24 Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes F. C. Lopes, Amanda Clin Epigenetics Review Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the nuclear DNA. As such, variations in nuclear gene expression as a consequence of mutations and epigenetic modifications can affect mitochondrial functionality. Conversely, the opposite could also be true. However, the relationship between mitochondrial dysfunction and epigenetics, such as nuclear DNA methylation, remains largely unexplored. Mitochondria function as central metabolic hubs controlling some of the main substrates involved in nuclear DNA methylation, via the one carbon metabolism, the tricarboxylic acid cycle and the methionine pathway. Here, we review key findings and highlight new areas of focus, with the ultimate goal of getting one step closer to understanding the genomic effects of mitochondrial dysfunction on nuclear epigenetic landscapes. BioMed Central 2020-11-23 /pmc/articles/PMC7684747/ /pubmed/33228792 http://dx.doi.org/10.1186/s13148-020-00976-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review F. C. Lopes, Amanda Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes |
title | Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes |
title_full | Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes |
title_fullStr | Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes |
title_full_unstemmed | Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes |
title_short | Mitochondrial metabolism and DNA methylation: a review of the interaction between two genomes |
title_sort | mitochondrial metabolism and dna methylation: a review of the interaction between two genomes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684747/ https://www.ncbi.nlm.nih.gov/pubmed/33228792 http://dx.doi.org/10.1186/s13148-020-00976-5 |
work_keys_str_mv | AT fclopesamanda mitochondrialmetabolismanddnamethylationareviewoftheinteractionbetweentwogenomes |