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Investigation of the clinical significance and pathological features of lanthanum deposition in the gastric mucosa
BACKGROUND: There are often specific endoscopic findings caused by deposition of lanthanum (La) in the gastric mucosa of patients taking lanthanum carbonate (LaC), a novel phosphate binder for patients on hemodialysis. We conducted a retrospective study to investigate the clinical significance of La...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684883/ https://www.ncbi.nlm.nih.gov/pubmed/33228604 http://dx.doi.org/10.1186/s12876-020-01545-z |
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author | Nishida, Shinya Ota, Kazuhiro Hattori, Kimiaki Iwatsubo, Taro Kawaguchi, Shimpei Kojima, Yuichi Takeuchi, Toshihisa Maeda, Tamaki Sakaguchi, Masahiro Higuchi, Kazuhide |
author_facet | Nishida, Shinya Ota, Kazuhiro Hattori, Kimiaki Iwatsubo, Taro Kawaguchi, Shimpei Kojima, Yuichi Takeuchi, Toshihisa Maeda, Tamaki Sakaguchi, Masahiro Higuchi, Kazuhide |
author_sort | Nishida, Shinya |
collection | PubMed |
description | BACKGROUND: There are often specific endoscopic findings caused by deposition of lanthanum (La) in the gastric mucosa of patients taking lanthanum carbonate (LaC), a novel phosphate binder for patients on hemodialysis. We conducted a retrospective study to investigate the clinical significance of La deposition in the gastric mucosa, and the association between endoscopic features and histologic findings in the same population. METHODS: We compared background factors in patients taking LaC with and without La deposition in their gastroscopic biopsy specimen. We also investigated the relationship between gastric endoscopic biopsy specimens with La deposition and the concurrent endoscopic images. RESULTS: There was a significant difference in the total dose of LaC between the La-positive and La-negative groups (990 g [180–3150 g] vs. 480 g [225–1328 g]; p = 0.013). In 27 biopsy specimens with specific whitish mucosa, 10 showed mild histiocytic infiltration and 17 showed severe infiltration. In contrast, among 24 specimens with non-whitish mucosa, 5 showed no histiocytic infiltration, 10 showed mild infiltration, and 9 showed severe infiltration. There was a significant relationship between endoscopic features and the degree of histiocytic infiltration (p = 0.026). CONCLUSIONS: We demonstrated that La deposition in the gastric mucosa depended on the total dose of LaC and was not affected by background factors. The specific endoscopic features of La deposition are associated with the infiltration of histiocytes, which represents the body’s normal response to foreign bodies. Trial registry The protocol was registered in the University Hospital Medical Information Network Clinical Trial Registry (UMIN000038929, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000044393). |
format | Online Article Text |
id | pubmed-7684883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76848832020-11-25 Investigation of the clinical significance and pathological features of lanthanum deposition in the gastric mucosa Nishida, Shinya Ota, Kazuhiro Hattori, Kimiaki Iwatsubo, Taro Kawaguchi, Shimpei Kojima, Yuichi Takeuchi, Toshihisa Maeda, Tamaki Sakaguchi, Masahiro Higuchi, Kazuhide BMC Gastroenterol Research Article BACKGROUND: There are often specific endoscopic findings caused by deposition of lanthanum (La) in the gastric mucosa of patients taking lanthanum carbonate (LaC), a novel phosphate binder for patients on hemodialysis. We conducted a retrospective study to investigate the clinical significance of La deposition in the gastric mucosa, and the association between endoscopic features and histologic findings in the same population. METHODS: We compared background factors in patients taking LaC with and without La deposition in their gastroscopic biopsy specimen. We also investigated the relationship between gastric endoscopic biopsy specimens with La deposition and the concurrent endoscopic images. RESULTS: There was a significant difference in the total dose of LaC between the La-positive and La-negative groups (990 g [180–3150 g] vs. 480 g [225–1328 g]; p = 0.013). In 27 biopsy specimens with specific whitish mucosa, 10 showed mild histiocytic infiltration and 17 showed severe infiltration. In contrast, among 24 specimens with non-whitish mucosa, 5 showed no histiocytic infiltration, 10 showed mild infiltration, and 9 showed severe infiltration. There was a significant relationship between endoscopic features and the degree of histiocytic infiltration (p = 0.026). CONCLUSIONS: We demonstrated that La deposition in the gastric mucosa depended on the total dose of LaC and was not affected by background factors. The specific endoscopic features of La deposition are associated with the infiltration of histiocytes, which represents the body’s normal response to foreign bodies. Trial registry The protocol was registered in the University Hospital Medical Information Network Clinical Trial Registry (UMIN000038929, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000044393). BioMed Central 2020-11-23 /pmc/articles/PMC7684883/ /pubmed/33228604 http://dx.doi.org/10.1186/s12876-020-01545-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Nishida, Shinya Ota, Kazuhiro Hattori, Kimiaki Iwatsubo, Taro Kawaguchi, Shimpei Kojima, Yuichi Takeuchi, Toshihisa Maeda, Tamaki Sakaguchi, Masahiro Higuchi, Kazuhide Investigation of the clinical significance and pathological features of lanthanum deposition in the gastric mucosa |
title | Investigation of the clinical significance and pathological features of lanthanum deposition in the gastric mucosa |
title_full | Investigation of the clinical significance and pathological features of lanthanum deposition in the gastric mucosa |
title_fullStr | Investigation of the clinical significance and pathological features of lanthanum deposition in the gastric mucosa |
title_full_unstemmed | Investigation of the clinical significance and pathological features of lanthanum deposition in the gastric mucosa |
title_short | Investigation of the clinical significance and pathological features of lanthanum deposition in the gastric mucosa |
title_sort | investigation of the clinical significance and pathological features of lanthanum deposition in the gastric mucosa |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684883/ https://www.ncbi.nlm.nih.gov/pubmed/33228604 http://dx.doi.org/10.1186/s12876-020-01545-z |
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