Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes

Recurrent RELA and YAP1 fusions are intimately associated with tumorigenesis in supratentorial ependymomas. Chromothripsis and focal copy number alterations involving 11q are hallmarks of these tumors. However, it is unknown whether the chromosomal alterations are a direct causal event resulting in...

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Detalles Bibliográficos
Autores principales: Takadera, Mutsumi, Satomi, Kaishi, Szulzewsky, Frank, Cimino, Patrick J., Holland, Eric C., Yamamoto, Tetsuya, Ichimura, Koichi, Ozawa, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684901/
https://www.ncbi.nlm.nih.gov/pubmed/33228790
http://dx.doi.org/10.1186/s40478-020-01080-8

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