Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice

The kinase TTBK1 is predominantly expressed in the central nervous system and has been implicated in neurodegenerative diseases including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis through its ability to phosphorylate the proteins tau and TDP-43. Mutati...

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Detalles Bibliográficos
Autores principales: McMillan, Pamela, Wheeler, Jeanna, Gatlin, Rachel E., Taylor, Laura, Strovas, Tim, Baum, Misa, Bird, Thomas D., Latimer, Caitlin, Keene, C. Dirk, Kraemer, Brian C., Liachko, Nicole F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684928/
https://www.ncbi.nlm.nih.gov/pubmed/33228809
http://dx.doi.org/10.1186/s40478-020-01073-7

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