Acute liver injury in a patient with adult-onset Still’s disease—the challenge of differential diagnosis

In addition to the cardinal symptoms of fever, rash and arthralgia, liver involvement in patients with adult-onset Still’s disease (AOSD) has been described. However, acute liver injury in AOSD patients can have various other causes: it can be a result of an AOSD-induced macrophage activation syndro...

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Autores principales: Weber, Sabine, Gerbes, Alexander L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685018/
https://www.ncbi.nlm.nih.gov/pubmed/33269085
http://dx.doi.org/10.1093/omcr/omaa102
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author Weber, Sabine
Gerbes, Alexander L
author_facet Weber, Sabine
Gerbes, Alexander L
author_sort Weber, Sabine
collection PubMed
description In addition to the cardinal symptoms of fever, rash and arthralgia, liver involvement in patients with adult-onset Still’s disease (AOSD) has been described. However, acute liver injury in AOSD patients can have various other causes: it can be a result of an AOSD-induced macrophage activation syndrome or be associated to the drugs given for the underlying diseases and symptoms. Differential diagnosis can therefore be challenging. We here present a case of a 32-year-old male with acute liver injury following the initial diagnosis of AOSD to discuss the possible underlying reasons.
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spelling pubmed-76850182020-12-01 Acute liver injury in a patient with adult-onset Still’s disease—the challenge of differential diagnosis Weber, Sabine Gerbes, Alexander L Oxf Med Case Reports Case Report In addition to the cardinal symptoms of fever, rash and arthralgia, liver involvement in patients with adult-onset Still’s disease (AOSD) has been described. However, acute liver injury in AOSD patients can have various other causes: it can be a result of an AOSD-induced macrophage activation syndrome or be associated to the drugs given for the underlying diseases and symptoms. Differential diagnosis can therefore be challenging. We here present a case of a 32-year-old male with acute liver injury following the initial diagnosis of AOSD to discuss the possible underlying reasons. Oxford University Press 2020-11-24 /pmc/articles/PMC7685018/ /pubmed/33269085 http://dx.doi.org/10.1093/omcr/omaa102 Text en © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Weber, Sabine
Gerbes, Alexander L
Acute liver injury in a patient with adult-onset Still’s disease—the challenge of differential diagnosis
title Acute liver injury in a patient with adult-onset Still’s disease—the challenge of differential diagnosis
title_full Acute liver injury in a patient with adult-onset Still’s disease—the challenge of differential diagnosis
title_fullStr Acute liver injury in a patient with adult-onset Still’s disease—the challenge of differential diagnosis
title_full_unstemmed Acute liver injury in a patient with adult-onset Still’s disease—the challenge of differential diagnosis
title_short Acute liver injury in a patient with adult-onset Still’s disease—the challenge of differential diagnosis
title_sort acute liver injury in a patient with adult-onset still’s disease—the challenge of differential diagnosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685018/
https://www.ncbi.nlm.nih.gov/pubmed/33269085
http://dx.doi.org/10.1093/omcr/omaa102
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