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Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools
Zika virus (ZIKV), an emerging arthropod-borne virus (arbovirus) of the Flaviviridae family, is a current issue worldwide, particularly because of the congenital and neurological syndromes associated with infection by this virus. As the initial clinical symptoms of all diseases caused by this group...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centro de Estudos de Venenos e Animais Peçonhentos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685096/ https://www.ncbi.nlm.nih.gov/pubmed/33281886 http://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0019 |
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author | Silva, Isaura Beatriz Borges da Silva, Aldacilene Souza Cunha, Mariana Sequetin Cabral, Aline Diniz de Oliveira, Kelly Cristina Alves Gaspari, Elizabeth De Prudencio, Carlos Roberto |
author_facet | Silva, Isaura Beatriz Borges da Silva, Aldacilene Souza Cunha, Mariana Sequetin Cabral, Aline Diniz de Oliveira, Kelly Cristina Alves Gaspari, Elizabeth De Prudencio, Carlos Roberto |
author_sort | Silva, Isaura Beatriz Borges |
collection | PubMed |
description | Zika virus (ZIKV), an emerging arthropod-borne virus (arbovirus) of the Flaviviridae family, is a current issue worldwide, particularly because of the congenital and neurological syndromes associated with infection by this virus. As the initial clinical symptoms of all diseases caused by this group are very similar, clinical diagnosis is difficult. Furthermore, laboratory diagnostic efforts have failed to identify specific and accurate tests for each virus of the Flaviviridae family due to the cross-reactivity of these viruses in serum samples. This situation has resulted in underreporting of the diseases caused by flaviviruses. However, many companies developed commercial diagnostic tests after the recent ZIKV outbreak. Moreover, health regulatory agencies have approved different commercial tests to extend the monitoring of ZIKV infections. Considering that a specific and sensitive diagnostic method for estimating risk and evaluating ZIKV propagation is still needed, this review aims to provide an update of the main commercially approved serological diagnostics test by the US Food and Drug Administration (FDA) and Brazilian National Health Surveillance Agency (ANVISA). Additionally, we present the technologies used for monoclonal antibody production as a tool for the development of diagnostic tests and applications of these antibodies in detecting ZIKV infections worldwide. |
format | Online Article Text |
id | pubmed-7685096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Centro de Estudos de Venenos e Animais Peçonhentos |
record_format | MEDLINE/PubMed |
spelling | pubmed-76850962020-12-03 Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools Silva, Isaura Beatriz Borges da Silva, Aldacilene Souza Cunha, Mariana Sequetin Cabral, Aline Diniz de Oliveira, Kelly Cristina Alves Gaspari, Elizabeth De Prudencio, Carlos Roberto J Venom Anim Toxins Incl Trop Dis Review Zika virus (ZIKV), an emerging arthropod-borne virus (arbovirus) of the Flaviviridae family, is a current issue worldwide, particularly because of the congenital and neurological syndromes associated with infection by this virus. As the initial clinical symptoms of all diseases caused by this group are very similar, clinical diagnosis is difficult. Furthermore, laboratory diagnostic efforts have failed to identify specific and accurate tests for each virus of the Flaviviridae family due to the cross-reactivity of these viruses in serum samples. This situation has resulted in underreporting of the diseases caused by flaviviruses. However, many companies developed commercial diagnostic tests after the recent ZIKV outbreak. Moreover, health regulatory agencies have approved different commercial tests to extend the monitoring of ZIKV infections. Considering that a specific and sensitive diagnostic method for estimating risk and evaluating ZIKV propagation is still needed, this review aims to provide an update of the main commercially approved serological diagnostics test by the US Food and Drug Administration (FDA) and Brazilian National Health Surveillance Agency (ANVISA). Additionally, we present the technologies used for monoclonal antibody production as a tool for the development of diagnostic tests and applications of these antibodies in detecting ZIKV infections worldwide. Centro de Estudos de Venenos e Animais Peçonhentos 2020-11-18 /pmc/articles/PMC7685096/ /pubmed/33281886 http://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0019 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Review Silva, Isaura Beatriz Borges da Silva, Aldacilene Souza Cunha, Mariana Sequetin Cabral, Aline Diniz de Oliveira, Kelly Cristina Alves Gaspari, Elizabeth De Prudencio, Carlos Roberto Zika virus serological diagnosis: commercial tests and monoclonal antibodies as tools |
title | Zika virus serological diagnosis: commercial tests and monoclonal
antibodies as tools |
title_full | Zika virus serological diagnosis: commercial tests and monoclonal
antibodies as tools |
title_fullStr | Zika virus serological diagnosis: commercial tests and monoclonal
antibodies as tools |
title_full_unstemmed | Zika virus serological diagnosis: commercial tests and monoclonal
antibodies as tools |
title_short | Zika virus serological diagnosis: commercial tests and monoclonal
antibodies as tools |
title_sort | zika virus serological diagnosis: commercial tests and monoclonal
antibodies as tools |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685096/ https://www.ncbi.nlm.nih.gov/pubmed/33281886 http://dx.doi.org/10.1590/1678-9199-JVATITD-2020-0019 |
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