Cargando…

Involvement of autophagy in MHC class I antigen presentation

MHC class I molecules on the cellular surface display peptides that either derive from endogenous proteins (self or viral), or from endocytosis of molecules, dying cells or pathogens. The conventional antigen‐processing pathway for MHC class I presentation depends on proteasome‐mediated degradation...

Descripción completa

Detalles Bibliográficos
Autor principal: Øynebråten, Inger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685157/
https://www.ncbi.nlm.nih.gov/pubmed/32969499
http://dx.doi.org/10.1111/sji.12978
_version_ 1783613137731190784
author Øynebråten, Inger
author_facet Øynebråten, Inger
author_sort Øynebråten, Inger
collection PubMed
description MHC class I molecules on the cellular surface display peptides that either derive from endogenous proteins (self or viral), or from endocytosis of molecules, dying cells or pathogens. The conventional antigen‐processing pathway for MHC class I presentation depends on proteasome‐mediated degradation of the protein followed by transporter associated with antigen‐processing (TAP)‐mediated transport of the generated peptides into the endoplasmic reticulum (ER). Here, peptides are loaded onto MHC I molecules before transportation to the cell surface. However, several alternative mechanisms have emerged. These include TAP‐independent mechanisms, the vacuolar pathway and involvement of autophagy. Autophagy is a cell intrinsic recycling system. It also functions as a defence mechanism that removes pathogens and damaged endocytic compartments from the cytosol. Therefore, it appears likely that autophagy would intersect with the MHC class I presentation pathway to alarm CD8(+) T cells of an ongoing intracellular infection. However, the importance of autophagy as a source of antigen for presentation on MHC I molecules remains to be defined. Here, original research papers which suggest involvement of autophagy in MHC I antigen presentation are reviewed. The antigens are from herpesvirus, cytomegalovirus and chlamydia. The studies point towards autophagy as important in MHC class I presentation of endogenous proteins during conditions of immune evasion. Because autophagy is a regulated process which is induced upon activation of, for example, pattern recognition receptors (PRRs), it will be crucial to use relevant stimulatory conditions together with primary cells when aiming to confirm the importance of autophagy in MHC class I antigen presentation in future studies.
format Online
Article
Text
id pubmed-7685157
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-76851572020-12-03 Involvement of autophagy in MHC class I antigen presentation Øynebråten, Inger Scand J Immunol Ssi 50 Years Anniversary Articles MHC class I molecules on the cellular surface display peptides that either derive from endogenous proteins (self or viral), or from endocytosis of molecules, dying cells or pathogens. The conventional antigen‐processing pathway for MHC class I presentation depends on proteasome‐mediated degradation of the protein followed by transporter associated with antigen‐processing (TAP)‐mediated transport of the generated peptides into the endoplasmic reticulum (ER). Here, peptides are loaded onto MHC I molecules before transportation to the cell surface. However, several alternative mechanisms have emerged. These include TAP‐independent mechanisms, the vacuolar pathway and involvement of autophagy. Autophagy is a cell intrinsic recycling system. It also functions as a defence mechanism that removes pathogens and damaged endocytic compartments from the cytosol. Therefore, it appears likely that autophagy would intersect with the MHC class I presentation pathway to alarm CD8(+) T cells of an ongoing intracellular infection. However, the importance of autophagy as a source of antigen for presentation on MHC I molecules remains to be defined. Here, original research papers which suggest involvement of autophagy in MHC I antigen presentation are reviewed. The antigens are from herpesvirus, cytomegalovirus and chlamydia. The studies point towards autophagy as important in MHC class I presentation of endogenous proteins during conditions of immune evasion. Because autophagy is a regulated process which is induced upon activation of, for example, pattern recognition receptors (PRRs), it will be crucial to use relevant stimulatory conditions together with primary cells when aiming to confirm the importance of autophagy in MHC class I antigen presentation in future studies. John Wiley and Sons Inc. 2020-10-19 2020-11 /pmc/articles/PMC7685157/ /pubmed/32969499 http://dx.doi.org/10.1111/sji.12978 Text en © 2020 The Authors. Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Scandinavian Foundation for Immunology This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Open access.
spellingShingle Ssi 50 Years Anniversary Articles
Øynebråten, Inger
Involvement of autophagy in MHC class I antigen presentation
title Involvement of autophagy in MHC class I antigen presentation
title_full Involvement of autophagy in MHC class I antigen presentation
title_fullStr Involvement of autophagy in MHC class I antigen presentation
title_full_unstemmed Involvement of autophagy in MHC class I antigen presentation
title_short Involvement of autophagy in MHC class I antigen presentation
title_sort involvement of autophagy in mhc class i antigen presentation
topic Ssi 50 Years Anniversary Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685157/
https://www.ncbi.nlm.nih.gov/pubmed/32969499
http://dx.doi.org/10.1111/sji.12978
work_keys_str_mv AT øynebrateninger involvementofautophagyinmhcclassiantigenpresentation