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Macrophages and scavenger receptors in obesity‐associated non‐alcoholic liver fatty disease (NAFLD)

With an increase in sedentary lifestyle and dietary over nutrition, obesity has become one of the major public health problems worldwide and is a prevalent predisposing risk factor to non‐alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in Western developed countries. NAF...

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Autores principales: Kragh Petersen, Sine, Bilkei‐Gorzo, Orsolya, Govaere, Olivier, Härtlova, Anetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685160/
https://www.ncbi.nlm.nih.gov/pubmed/32892401
http://dx.doi.org/10.1111/sji.12971
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author Kragh Petersen, Sine
Bilkei‐Gorzo, Orsolya
Govaere, Olivier
Härtlova, Anetta
author_facet Kragh Petersen, Sine
Bilkei‐Gorzo, Orsolya
Govaere, Olivier
Härtlova, Anetta
author_sort Kragh Petersen, Sine
collection PubMed
description With an increase in sedentary lifestyle and dietary over nutrition, obesity has become one of the major public health problems worldwide and is a prevalent predisposing risk factor to non‐alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in Western developed countries. NAFLD represents a series of diseased states ranging from non‐alcoholic fatty liver (NAFL) to steatohepatitis (NASH), which can lead to fibrosis and eventually to cirrhosis and hepatocellular carcinoma. Currently, the only effective treatment to cure end‐stage liver disease is liver transplantation. Macrophages have been reported to play a crucial role in the progression of NAFLD, thereby are a potential target for therapy. In this review, we discuss the current knowledge on the role of macrophages and inflammatory signalling pathways associated with obesity and chronic liver inflammation, and their contribution to NAFLD development and progression.
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spelling pubmed-76851602020-12-03 Macrophages and scavenger receptors in obesity‐associated non‐alcoholic liver fatty disease (NAFLD) Kragh Petersen, Sine Bilkei‐Gorzo, Orsolya Govaere, Olivier Härtlova, Anetta Scand J Immunol Ssi 50 Years Anniversary Articles With an increase in sedentary lifestyle and dietary over nutrition, obesity has become one of the major public health problems worldwide and is a prevalent predisposing risk factor to non‐alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in Western developed countries. NAFLD represents a series of diseased states ranging from non‐alcoholic fatty liver (NAFL) to steatohepatitis (NASH), which can lead to fibrosis and eventually to cirrhosis and hepatocellular carcinoma. Currently, the only effective treatment to cure end‐stage liver disease is liver transplantation. Macrophages have been reported to play a crucial role in the progression of NAFLD, thereby are a potential target for therapy. In this review, we discuss the current knowledge on the role of macrophages and inflammatory signalling pathways associated with obesity and chronic liver inflammation, and their contribution to NAFLD development and progression. John Wiley and Sons Inc. 2020-09-21 2020-11 /pmc/articles/PMC7685160/ /pubmed/32892401 http://dx.doi.org/10.1111/sji.12971 Text en © 2020 The Authors. Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Scandinavian Foundation for Immunology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Ssi 50 Years Anniversary Articles
Kragh Petersen, Sine
Bilkei‐Gorzo, Orsolya
Govaere, Olivier
Härtlova, Anetta
Macrophages and scavenger receptors in obesity‐associated non‐alcoholic liver fatty disease (NAFLD)
title Macrophages and scavenger receptors in obesity‐associated non‐alcoholic liver fatty disease (NAFLD)
title_full Macrophages and scavenger receptors in obesity‐associated non‐alcoholic liver fatty disease (NAFLD)
title_fullStr Macrophages and scavenger receptors in obesity‐associated non‐alcoholic liver fatty disease (NAFLD)
title_full_unstemmed Macrophages and scavenger receptors in obesity‐associated non‐alcoholic liver fatty disease (NAFLD)
title_short Macrophages and scavenger receptors in obesity‐associated non‐alcoholic liver fatty disease (NAFLD)
title_sort macrophages and scavenger receptors in obesity‐associated non‐alcoholic liver fatty disease (nafld)
topic Ssi 50 Years Anniversary Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685160/
https://www.ncbi.nlm.nih.gov/pubmed/32892401
http://dx.doi.org/10.1111/sji.12971
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