An engineered receptor-binding domain improves the immunogenicity of multivalent SARS-CoV-2 vaccines

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The SARS-coronavirus 2 (SARS-CoV-2) spike (S) protein mediates viral entry into cells expressing the angiotensin-converting enzyme 2 (ACE2). The S protein engages ACE2 through its receptor-binding domain (RBD), an independently folded 197-amino acid fragment of the 1273-amino acid S-protein protomer...

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Detalles Bibliográficos
Autores principales: Quinlan, Brian D., He, Wenhui, Mou, Huihui, Zhang, Lizhou, Guo, Yan, Chang, Jing, Peng, Shoujiao, Ojha, Amrita, Tavora, Rubens, Parcells, Mark S., Luo, Guangxiang, Li, Wenhui, Zhong, Guocai, Choe, Hyeryun, Farzan, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685318/
https://www.ncbi.nlm.nih.gov/pubmed/33236008
http://dx.doi.org/10.1101/2020.11.18.388934
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