Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

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Age is the dominant risk factor for infectious diseases, but the mechanisms linking the two are incompletely understood1,2. Age-related mosaic chromosomal alterations (mCAs) detected from blood-derived DNA genotyping, are structural somatic variants associated with aberrant leukocyte cell counts, he...

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Detalles Bibliográficos
Autores principales: Natarajan, Pradeep, Zekavat, Seyedeh, Lin, Shu-Hong, Bick, Alexander, Liu, Aoxing, Paruchuri, Kaavya, Uddin, Md Mesbah, Ye, Yixuan, Yu, Zhaolong, Liu, Xiaoxi, Kamatani, Yoichiro, Pirruccello, James, Pampana, Akhil, Loh, Po-Ru, Kohli, Puja, McCarroll, Steven, Neale, Benjamin, Engels, Eric, Brown, Derek, Smoller, Jordan, Green, Robert, Karlson, Elizabeth, Lebo, Matthew, Ellinor, Patrick, Weiss, Scott, Daly, Mark, Terao, Chikashi, Zhao, Hongyu, Ebert, Benjamin, Machiela, Mitchell, Genovese, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685327/
https://www.ncbi.nlm.nih.gov/pubmed/33236004
http://dx.doi.org/10.21203/rs.3.rs-100817/v1
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