Hematopoietic mosaic chromosomal alterations and risk for infection among 767,891 individuals without blood cancer

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Age is the dominant risk factor for infectious diseases, but the mechanisms linking the two are incompletely understood(1,2). Age-related mosaic chromosomal alterations (mCAs) detected from blood-derived DNA genotyping, are structural somatic variants associated with aberrant leukocyte cell counts,...

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Detalles Bibliográficos
Autores principales: Zekavat, Seyedeh M., Lin, Shu-Hong, Bick, Alexander G., Liu, Aoxing, Paruchuri, Kaavya, Uddin, Md Mesbah, Ye, Yixuan, Yu, Zhaolong, Liu, Xiaoxi, Kamatani, Yoichiro, Pirruccello, James P., Pampana, Akhil, Loh, Po-Ru, Kohli, Puja, McCarroll, Steven A., Neale, Benjamin, Engels, Eric A., Brown, Derek W., Smoller, Jordan W., Green, Robert, Karlson, Elizabeth W., Lebo, Matthew, Ellinor, Patrick T., Weiss, Scott T., Daly, Mark J., Terao, Chikashi, Zhao, Hongyu, Ebert, Benjamin L., Ganna, Andrea, Machiela, Mitchell J., Genovese, Giulio, Natarajan, Pradeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685330/
https://www.ncbi.nlm.nih.gov/pubmed/33236019
http://dx.doi.org/10.1101/2020.11.12.20230821
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