Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice

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Protection against SARS-CoV-2 and SARS-related emergent zoonotic coronaviruses is urgently needed. We made homotypic nanoparticles displaying the receptor-binding domain (RBD) of SARS-CoV-2 or co-displaying SARS-CoV-2 RBD along with RBDs from animal betacoronaviruses that represent threats to humans...

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Detalles Bibliográficos
Autores principales: Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Lee, Yu E., Hoffman, Pauline R., Ou, Susan, Kakutani, Leesa M., Keeffe, Jennifer R., Wu, Hung-Jen, Howarth, Mark, West, Anthony P., Barnes, Christopher O., Nussenzweig, Michel C., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685334/
https://www.ncbi.nlm.nih.gov/pubmed/33236016
http://dx.doi.org/10.1101/2020.11.17.387092
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