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Quantitative DCE-MRI: an efficient diagnostic technique for evaluating early micro-environment permeability changes in ankylosing spondylitis
BACKGROUND: In the management of early inflammatory joint of ankylosing spondylitis (AS), there is a need for reliable noninvasive quantitative monitoring biomarker to closely assess status of synovitis progression. Cognizant to this,studies geared on improving techniques for quantitative evaluation...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685584/ https://www.ncbi.nlm.nih.gov/pubmed/33234145 http://dx.doi.org/10.1186/s12891-020-03805-1 |
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author | Yang, Hui Jiang, Ling Li, Jiang Zheng, Xiuzhu Yao, Qianqian Li, Changqin Zhu, Jianzhong Qin, Jian |
author_facet | Yang, Hui Jiang, Ling Li, Jiang Zheng, Xiuzhu Yao, Qianqian Li, Changqin Zhu, Jianzhong Qin, Jian |
author_sort | Yang, Hui |
collection | PubMed |
description | BACKGROUND: In the management of early inflammatory joint of ankylosing spondylitis (AS), there is a need for reliable noninvasive quantitative monitoring biomarker to closely assess status of synovitis progression. Cognizant to this,studies geared on improving techniques for quantitative evaluation of micro-environment permeability of the joint space are necessary. Such improved techniques may provide tissue perfusion as important biological parameters and can further help in understanding the origin of early changes associated with AS. The purpose of this study was to prospectively evaluate the diagnostic performance and determine longitudinal relationships of early micro-environment active in the joint space of the sacroiliac joint (SIJ) with a rat model by using quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). METHODS: Thirty wistar male rats were randomly assigned to the model (n = 15) or control (n = 15) group. All rats underwent DCE-MRI of SIJ region at fixed time points (12, 17 and 22 weeks),between September 2018 and October 2019. Differences in permeability parameters between the two groups at the same time point were compared by using an independent samples t test. Spearman correlations of DCE-MRI parameters with different time points in model group were analyzed. All statistical analyses were performed with software. RESULTS: At 12 weeks,the K(trans),K(ep) and V(e) values in the model group were slightly lower than those in control group,but all the differences were not statistically significant (p > 0.05). Compared with control group,the transfer constant (K(trans)) values increased significantly at 17 weeks and 22 weeks in model group,while the rate constant (K(ep)) and volume of extravascular extracellular space (V(e)) significantly increased only at 22 weeks(p < 0.05). The K(trans),K(ep) and V(e) were positively correlated with increasing time points (r = 0.946, P<0.01 for K(trans); r = 0.945, P<0.01 for K(ep); and r = 0.832, P<0.01 for V(e)). CONCLUSION: Quantitative DCE-MRI parameters are valuable for evaluating the early longitudinal relationship of micro-environment permeability changes in the joint space of SIJ. |
format | Online Article Text |
id | pubmed-7685584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76855842020-11-25 Quantitative DCE-MRI: an efficient diagnostic technique for evaluating early micro-environment permeability changes in ankylosing spondylitis Yang, Hui Jiang, Ling Li, Jiang Zheng, Xiuzhu Yao, Qianqian Li, Changqin Zhu, Jianzhong Qin, Jian BMC Musculoskelet Disord Research Article BACKGROUND: In the management of early inflammatory joint of ankylosing spondylitis (AS), there is a need for reliable noninvasive quantitative monitoring biomarker to closely assess status of synovitis progression. Cognizant to this,studies geared on improving techniques for quantitative evaluation of micro-environment permeability of the joint space are necessary. Such improved techniques may provide tissue perfusion as important biological parameters and can further help in understanding the origin of early changes associated with AS. The purpose of this study was to prospectively evaluate the diagnostic performance and determine longitudinal relationships of early micro-environment active in the joint space of the sacroiliac joint (SIJ) with a rat model by using quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). METHODS: Thirty wistar male rats were randomly assigned to the model (n = 15) or control (n = 15) group. All rats underwent DCE-MRI of SIJ region at fixed time points (12, 17 and 22 weeks),between September 2018 and October 2019. Differences in permeability parameters between the two groups at the same time point were compared by using an independent samples t test. Spearman correlations of DCE-MRI parameters with different time points in model group were analyzed. All statistical analyses were performed with software. RESULTS: At 12 weeks,the K(trans),K(ep) and V(e) values in the model group were slightly lower than those in control group,but all the differences were not statistically significant (p > 0.05). Compared with control group,the transfer constant (K(trans)) values increased significantly at 17 weeks and 22 weeks in model group,while the rate constant (K(ep)) and volume of extravascular extracellular space (V(e)) significantly increased only at 22 weeks(p < 0.05). The K(trans),K(ep) and V(e) were positively correlated with increasing time points (r = 0.946, P<0.01 for K(trans); r = 0.945, P<0.01 for K(ep); and r = 0.832, P<0.01 for V(e)). CONCLUSION: Quantitative DCE-MRI parameters are valuable for evaluating the early longitudinal relationship of micro-environment permeability changes in the joint space of SIJ. BioMed Central 2020-11-24 /pmc/articles/PMC7685584/ /pubmed/33234145 http://dx.doi.org/10.1186/s12891-020-03805-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Yang, Hui Jiang, Ling Li, Jiang Zheng, Xiuzhu Yao, Qianqian Li, Changqin Zhu, Jianzhong Qin, Jian Quantitative DCE-MRI: an efficient diagnostic technique for evaluating early micro-environment permeability changes in ankylosing spondylitis |
title | Quantitative DCE-MRI: an efficient diagnostic technique for evaluating early micro-environment permeability changes in ankylosing spondylitis |
title_full | Quantitative DCE-MRI: an efficient diagnostic technique for evaluating early micro-environment permeability changes in ankylosing spondylitis |
title_fullStr | Quantitative DCE-MRI: an efficient diagnostic technique for evaluating early micro-environment permeability changes in ankylosing spondylitis |
title_full_unstemmed | Quantitative DCE-MRI: an efficient diagnostic technique for evaluating early micro-environment permeability changes in ankylosing spondylitis |
title_short | Quantitative DCE-MRI: an efficient diagnostic technique for evaluating early micro-environment permeability changes in ankylosing spondylitis |
title_sort | quantitative dce-mri: an efficient diagnostic technique for evaluating early micro-environment permeability changes in ankylosing spondylitis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685584/ https://www.ncbi.nlm.nih.gov/pubmed/33234145 http://dx.doi.org/10.1186/s12891-020-03805-1 |
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