Cargando…
Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke
Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective eff...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685793/ https://www.ncbi.nlm.nih.gov/pubmed/33282940 http://dx.doi.org/10.1155/2020/2196207 |
_version_ | 1783613237560868864 |
---|---|
author | Machado-Junior, Pedro A. Araújo, Natália P. S. Souza, Ana B. F. Castro, Thalles F. Oliveira, Michel Costa, Guilherme P. Matos, Natália A. Vieira, Paula M. A. Talvani, André Bezerra, Frank S. Cangussú, Sílvia D. |
author_facet | Machado-Junior, Pedro A. Araújo, Natália P. S. Souza, Ana B. F. Castro, Thalles F. Oliveira, Michel Costa, Guilherme P. Matos, Natália A. Vieira, Paula M. A. Talvani, André Bezerra, Frank S. Cangussú, Sílvia D. |
author_sort | Machado-Junior, Pedro A. |
collection | PubMed |
description | Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin on livers from mice exposed to long-term cigarette smoke exposure. Male C57BL/6 mice were divided into five groups: control (CG), vehicle (VG), quercetin (QG), cigarette smoke (CSG), quercetin, and cigarette smoke (QCSG). CSG and QCSG were exposed to cigarette smoke for sixty consecutive days; at the end of the exposures, all animals were euthanized. Mice that received quercetin daily and were exposed to cigarette smoke showed a reduced influx of inflammatory cells, oxidative stress, inflammatory reaction, and histopathological changes in the liver, compared to CSG. These results suggest that quercetin may be an effective adjuvant for treating damage to the liver due to cigarette smoke exposure. |
format | Online Article Text |
id | pubmed-7685793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-76857932020-12-04 Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke Machado-Junior, Pedro A. Araújo, Natália P. S. Souza, Ana B. F. Castro, Thalles F. Oliveira, Michel Costa, Guilherme P. Matos, Natália A. Vieira, Paula M. A. Talvani, André Bezerra, Frank S. Cangussú, Sílvia D. Biomed Res Int Research Article Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin on livers from mice exposed to long-term cigarette smoke exposure. Male C57BL/6 mice were divided into five groups: control (CG), vehicle (VG), quercetin (QG), cigarette smoke (CSG), quercetin, and cigarette smoke (QCSG). CSG and QCSG were exposed to cigarette smoke for sixty consecutive days; at the end of the exposures, all animals were euthanized. Mice that received quercetin daily and were exposed to cigarette smoke showed a reduced influx of inflammatory cells, oxidative stress, inflammatory reaction, and histopathological changes in the liver, compared to CSG. These results suggest that quercetin may be an effective adjuvant for treating damage to the liver due to cigarette smoke exposure. Hindawi 2020-11-15 /pmc/articles/PMC7685793/ /pubmed/33282940 http://dx.doi.org/10.1155/2020/2196207 Text en Copyright © 2020 Pedro A. Machado-Junior et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Machado-Junior, Pedro A. Araújo, Natália P. S. Souza, Ana B. F. Castro, Thalles F. Oliveira, Michel Costa, Guilherme P. Matos, Natália A. Vieira, Paula M. A. Talvani, André Bezerra, Frank S. Cangussú, Sílvia D. Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke |
title | Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke |
title_full | Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke |
title_fullStr | Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke |
title_full_unstemmed | Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke |
title_short | Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke |
title_sort | protective effects of quercetin on livers from mice exposed to long-term cigarette smoke |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685793/ https://www.ncbi.nlm.nih.gov/pubmed/33282940 http://dx.doi.org/10.1155/2020/2196207 |
work_keys_str_mv | AT machadojuniorpedroa protectiveeffectsofquercetinonliversfrommiceexposedtolongtermcigarettesmoke AT araujonataliaps protectiveeffectsofquercetinonliversfrommiceexposedtolongtermcigarettesmoke AT souzaanabf protectiveeffectsofquercetinonliversfrommiceexposedtolongtermcigarettesmoke AT castrothallesf protectiveeffectsofquercetinonliversfrommiceexposedtolongtermcigarettesmoke AT oliveiramichel protectiveeffectsofquercetinonliversfrommiceexposedtolongtermcigarettesmoke AT costaguilhermep protectiveeffectsofquercetinonliversfrommiceexposedtolongtermcigarettesmoke AT matosnataliaa protectiveeffectsofquercetinonliversfrommiceexposedtolongtermcigarettesmoke AT vieirapaulama protectiveeffectsofquercetinonliversfrommiceexposedtolongtermcigarettesmoke AT talvaniandre protectiveeffectsofquercetinonliversfrommiceexposedtolongtermcigarettesmoke AT bezerrafranks protectiveeffectsofquercetinonliversfrommiceexposedtolongtermcigarettesmoke AT cangussusilviad protectiveeffectsofquercetinonliversfrommiceexposedtolongtermcigarettesmoke |