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Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke

Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective eff...

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Autores principales: Machado-Junior, Pedro A., Araújo, Natália P. S., Souza, Ana B. F., Castro, Thalles F., Oliveira, Michel, Costa, Guilherme P., Matos, Natália A., Vieira, Paula M. A., Talvani, André, Bezerra, Frank S., Cangussú, Sílvia D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685793/
https://www.ncbi.nlm.nih.gov/pubmed/33282940
http://dx.doi.org/10.1155/2020/2196207
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author Machado-Junior, Pedro A.
Araújo, Natália P. S.
Souza, Ana B. F.
Castro, Thalles F.
Oliveira, Michel
Costa, Guilherme P.
Matos, Natália A.
Vieira, Paula M. A.
Talvani, André
Bezerra, Frank S.
Cangussú, Sílvia D.
author_facet Machado-Junior, Pedro A.
Araújo, Natália P. S.
Souza, Ana B. F.
Castro, Thalles F.
Oliveira, Michel
Costa, Guilherme P.
Matos, Natália A.
Vieira, Paula M. A.
Talvani, André
Bezerra, Frank S.
Cangussú, Sílvia D.
author_sort Machado-Junior, Pedro A.
collection PubMed
description Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin on livers from mice exposed to long-term cigarette smoke exposure. Male C57BL/6 mice were divided into five groups: control (CG), vehicle (VG), quercetin (QG), cigarette smoke (CSG), quercetin, and cigarette smoke (QCSG). CSG and QCSG were exposed to cigarette smoke for sixty consecutive days; at the end of the exposures, all animals were euthanized. Mice that received quercetin daily and were exposed to cigarette smoke showed a reduced influx of inflammatory cells, oxidative stress, inflammatory reaction, and histopathological changes in the liver, compared to CSG. These results suggest that quercetin may be an effective adjuvant for treating damage to the liver due to cigarette smoke exposure.
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spelling pubmed-76857932020-12-04 Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke Machado-Junior, Pedro A. Araújo, Natália P. S. Souza, Ana B. F. Castro, Thalles F. Oliveira, Michel Costa, Guilherme P. Matos, Natália A. Vieira, Paula M. A. Talvani, André Bezerra, Frank S. Cangussú, Sílvia D. Biomed Res Int Research Article Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin on livers from mice exposed to long-term cigarette smoke exposure. Male C57BL/6 mice were divided into five groups: control (CG), vehicle (VG), quercetin (QG), cigarette smoke (CSG), quercetin, and cigarette smoke (QCSG). CSG and QCSG were exposed to cigarette smoke for sixty consecutive days; at the end of the exposures, all animals were euthanized. Mice that received quercetin daily and were exposed to cigarette smoke showed a reduced influx of inflammatory cells, oxidative stress, inflammatory reaction, and histopathological changes in the liver, compared to CSG. These results suggest that quercetin may be an effective adjuvant for treating damage to the liver due to cigarette smoke exposure. Hindawi 2020-11-15 /pmc/articles/PMC7685793/ /pubmed/33282940 http://dx.doi.org/10.1155/2020/2196207 Text en Copyright © 2020 Pedro A. Machado-Junior et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Machado-Junior, Pedro A.
Araújo, Natália P. S.
Souza, Ana B. F.
Castro, Thalles F.
Oliveira, Michel
Costa, Guilherme P.
Matos, Natália A.
Vieira, Paula M. A.
Talvani, André
Bezerra, Frank S.
Cangussú, Sílvia D.
Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke
title Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke
title_full Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke
title_fullStr Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke
title_full_unstemmed Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke
title_short Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke
title_sort protective effects of quercetin on livers from mice exposed to long-term cigarette smoke
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685793/
https://www.ncbi.nlm.nih.gov/pubmed/33282940
http://dx.doi.org/10.1155/2020/2196207
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