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Diagnostic Criteria of Postoperative Cognitive Dysfunction: A Focused Systematic Review

Postoperative Cognitive Dysfunction (POCD) is characterized by a deterioration in cognitive performance after surgery and is increasingly addressed in research studies. However, a uniform definition of POCD seems to be lacking, which is a major threat to clinical research in this area. We performed...

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Autores principales: van Sinderen, Kim, Schwarte, Lothar A., Schober, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685826/
https://www.ncbi.nlm.nih.gov/pubmed/33281900
http://dx.doi.org/10.1155/2020/7384394
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author van Sinderen, Kim
Schwarte, Lothar A.
Schober, Patrick
author_facet van Sinderen, Kim
Schwarte, Lothar A.
Schober, Patrick
author_sort van Sinderen, Kim
collection PubMed
description Postoperative Cognitive Dysfunction (POCD) is characterized by a deterioration in cognitive performance after surgery and is increasingly addressed in research studies. However, a uniform definition of POCD seems to be lacking, which is a major threat to clinical research in this area. We performed a focused systematic review to determine the current degree of heterogeneity in how POCD is defined across studies and to identify those diagnostic criteria that are used most commonly. The search identified 173 records, of which 30 were included. Neurocognitive testing was most commonly performed shortly before surgery and at 7 days postoperatively. A variety of neurocognitive tests were used to test a range of cognitive domains, including complex attention, language, executive functioning, perceptual-motor function, and learning and memory. The tests that were used most commonly were the Mini-Mental State Examination, the digit span test, the trail making test part A, and the digit symbol substitution test, but consensus on which test result would be considered “positive” for POCD was sparse. The results of this systematic review suggest the lack of a consistent approach towards defining POCD. However, commonalities were identified which may serve as a common denominator for deriving consensus-based diagnostic guidelines for POCD.
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spelling pubmed-76858262020-12-04 Diagnostic Criteria of Postoperative Cognitive Dysfunction: A Focused Systematic Review van Sinderen, Kim Schwarte, Lothar A. Schober, Patrick Anesthesiol Res Pract Review Article Postoperative Cognitive Dysfunction (POCD) is characterized by a deterioration in cognitive performance after surgery and is increasingly addressed in research studies. However, a uniform definition of POCD seems to be lacking, which is a major threat to clinical research in this area. We performed a focused systematic review to determine the current degree of heterogeneity in how POCD is defined across studies and to identify those diagnostic criteria that are used most commonly. The search identified 173 records, of which 30 were included. Neurocognitive testing was most commonly performed shortly before surgery and at 7 days postoperatively. A variety of neurocognitive tests were used to test a range of cognitive domains, including complex attention, language, executive functioning, perceptual-motor function, and learning and memory. The tests that were used most commonly were the Mini-Mental State Examination, the digit span test, the trail making test part A, and the digit symbol substitution test, but consensus on which test result would be considered “positive” for POCD was sparse. The results of this systematic review suggest the lack of a consistent approach towards defining POCD. However, commonalities were identified which may serve as a common denominator for deriving consensus-based diagnostic guidelines for POCD. Hindawi 2020-11-16 /pmc/articles/PMC7685826/ /pubmed/33281900 http://dx.doi.org/10.1155/2020/7384394 Text en Copyright © 2020 Kim van Sinderen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
van Sinderen, Kim
Schwarte, Lothar A.
Schober, Patrick
Diagnostic Criteria of Postoperative Cognitive Dysfunction: A Focused Systematic Review
title Diagnostic Criteria of Postoperative Cognitive Dysfunction: A Focused Systematic Review
title_full Diagnostic Criteria of Postoperative Cognitive Dysfunction: A Focused Systematic Review
title_fullStr Diagnostic Criteria of Postoperative Cognitive Dysfunction: A Focused Systematic Review
title_full_unstemmed Diagnostic Criteria of Postoperative Cognitive Dysfunction: A Focused Systematic Review
title_short Diagnostic Criteria of Postoperative Cognitive Dysfunction: A Focused Systematic Review
title_sort diagnostic criteria of postoperative cognitive dysfunction: a focused systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685826/
https://www.ncbi.nlm.nih.gov/pubmed/33281900
http://dx.doi.org/10.1155/2020/7384394
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