Cargando…
Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation
Experimental studies have shown that astrocytes participate in epilepsy through inducing the release of glutamate. Meanwhile, considering the disinhibition circuit among inhibitory neuronal populations with different time scales and the feedforward inhibition connection from thalamic relay nucleus t...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685866/ https://www.ncbi.nlm.nih.gov/pubmed/33281896 http://dx.doi.org/10.1155/2020/8867509 |
_version_ | 1783613253679579136 |
---|---|
author | Zhang, Honghui Shen, Zhuan Zhao, Qiangui Yan, Luyao Du, Lin Deng, Zichen |
author_facet | Zhang, Honghui Shen, Zhuan Zhao, Qiangui Yan, Luyao Du, Lin Deng, Zichen |
author_sort | Zhang, Honghui |
collection | PubMed |
description | Experimental studies have shown that astrocytes participate in epilepsy through inducing the release of glutamate. Meanwhile, considering the disinhibition circuit among inhibitory neuronal populations with different time scales and the feedforward inhibition connection from thalamic relay nucleus to cortical inhibitory neuronal population, here, we propose a modified thalamocortical field model to systematically investigate the mechanism of epilepsy. Firstly, our results show that rich firing activities can be induced by astrocyte dysfunction, including high or low saturated state, high- or low-frequency clonic, spike-wave discharge (SWD), and tonic. More importantly, with the enhancement of feedforward inhibition connection, SWD and tonic oscillations will disappear. In other words, all these pathological waveforms can be suppressed or eliminated. Then, we explore the control effects after different external stimulations applying to thalamic neuronal population. We find that single-pulse stimulation can not only suppress but also induce pathological firing patterns, such as SWD, tonic, and clonic oscillations. And we further verify that deep brain stimulation can control absence epilepsy by regulating the amplitude and pulse width of stimulation. In addition, based on our modified model, 3 : 2 coordinated reset stimulation strategies with different intensities are compared and a more effective and safer stimulation mode is proposed. Our conclusions are expected to give more theoretical insights into the treatment of epilepsy. |
format | Online Article Text |
id | pubmed-7685866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-76858662020-12-04 Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation Zhang, Honghui Shen, Zhuan Zhao, Qiangui Yan, Luyao Du, Lin Deng, Zichen Neural Plast Research Article Experimental studies have shown that astrocytes participate in epilepsy through inducing the release of glutamate. Meanwhile, considering the disinhibition circuit among inhibitory neuronal populations with different time scales and the feedforward inhibition connection from thalamic relay nucleus to cortical inhibitory neuronal population, here, we propose a modified thalamocortical field model to systematically investigate the mechanism of epilepsy. Firstly, our results show that rich firing activities can be induced by astrocyte dysfunction, including high or low saturated state, high- or low-frequency clonic, spike-wave discharge (SWD), and tonic. More importantly, with the enhancement of feedforward inhibition connection, SWD and tonic oscillations will disappear. In other words, all these pathological waveforms can be suppressed or eliminated. Then, we explore the control effects after different external stimulations applying to thalamic neuronal population. We find that single-pulse stimulation can not only suppress but also induce pathological firing patterns, such as SWD, tonic, and clonic oscillations. And we further verify that deep brain stimulation can control absence epilepsy by regulating the amplitude and pulse width of stimulation. In addition, based on our modified model, 3 : 2 coordinated reset stimulation strategies with different intensities are compared and a more effective and safer stimulation mode is proposed. Our conclusions are expected to give more theoretical insights into the treatment of epilepsy. Hindawi 2020-11-16 /pmc/articles/PMC7685866/ /pubmed/33281896 http://dx.doi.org/10.1155/2020/8867509 Text en Copyright © 2020 Honghui Zhang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Honghui Shen, Zhuan Zhao, Qiangui Yan, Luyao Du, Lin Deng, Zichen Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation |
title | Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation |
title_full | Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation |
title_fullStr | Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation |
title_full_unstemmed | Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation |
title_short | Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation |
title_sort | dynamic transitions of epilepsy waveforms induced by astrocyte dysfunction and electrical stimulation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685866/ https://www.ncbi.nlm.nih.gov/pubmed/33281896 http://dx.doi.org/10.1155/2020/8867509 |
work_keys_str_mv | AT zhanghonghui dynamictransitionsofepilepsywaveformsinducedbyastrocytedysfunctionandelectricalstimulation AT shenzhuan dynamictransitionsofepilepsywaveformsinducedbyastrocytedysfunctionandelectricalstimulation AT zhaoqiangui dynamictransitionsofepilepsywaveformsinducedbyastrocytedysfunctionandelectricalstimulation AT yanluyao dynamictransitionsofepilepsywaveformsinducedbyastrocytedysfunctionandelectricalstimulation AT dulin dynamictransitionsofepilepsywaveformsinducedbyastrocytedysfunctionandelectricalstimulation AT dengzichen dynamictransitionsofepilepsywaveformsinducedbyastrocytedysfunctionandelectricalstimulation |