Melanoma with in-frame deletion of MAP2K1: a distinct molecular subtype of cutaneous melanoma mutually exclusive from BRAF, NRAS, and NF1 mutations

While the genomics of BRAF, NRAS, and other key genes influencing MAP kinase (MAPK) activity have been thoroughly characterized in melanoma, mutations in MAP2K1 (MEK1) have received significantly less attention and have consisted almost entirely of missense mutations considered secondary oncogenic d...

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Detalles Bibliográficos
Autores principales: Williams, Erik A., Montesion, Meagan, Shah, Nikunj, Sharaf, Radwa, Pavlick, Dean C., Sokol, Ethan S., Alexander, Brian, Venstrom, Jeff, Elvin, Julia A., Ross, Jeffrey S., Williams, Kevin Jon, Tse, Julie Y., Mochel, Mark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685971/
https://www.ncbi.nlm.nih.gov/pubmed/32483240
http://dx.doi.org/10.1038/s41379-020-0581-5

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