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The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices

Medical device contamination caused by microbial pathogens such as bacteria and fungi has posed a severe threat to the patients’ health in hospitals. Due to the increasing resistance of pathogens to antibiotics, the efficacy of traditional antibiotics treatment is gradually decreasing for the infect...

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Autores principales: Qiu, Haofeng, Si, Zhangyong, Luo, Yang, Feng, Peipei, Wu, Xujin, Hou, Wenjia, Zhu, Yabin, Chan-Park, Mary B., Xu, Long, Huang, Dongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686044/
https://www.ncbi.nlm.nih.gov/pubmed/33262975
http://dx.doi.org/10.3389/fbioe.2020.00910
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author Qiu, Haofeng
Si, Zhangyong
Luo, Yang
Feng, Peipei
Wu, Xujin
Hou, Wenjia
Zhu, Yabin
Chan-Park, Mary B.
Xu, Long
Huang, Dongmei
author_facet Qiu, Haofeng
Si, Zhangyong
Luo, Yang
Feng, Peipei
Wu, Xujin
Hou, Wenjia
Zhu, Yabin
Chan-Park, Mary B.
Xu, Long
Huang, Dongmei
author_sort Qiu, Haofeng
collection PubMed
description Medical device contamination caused by microbial pathogens such as bacteria and fungi has posed a severe threat to the patients’ health in hospitals. Due to the increasing resistance of pathogens to antibiotics, the efficacy of traditional antibiotics treatment is gradually decreasing for the infection treatment. Therefore, it is urgent to develop new antibacterial drugs to meet clinical or civilian needs. Antibacterial polymers have attracted the interests of researchers due to their unique bactericidal mechanism and excellent antibacterial effect. This article reviews the mechanism and advantages of antimicrobial polymers and the consideration for their translation. Their applications and advances in medical device surface coating were also reviewed. The information will provide a valuable reference to design and develop antibacterial devices that are resistant to pathogenic infections.
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spelling pubmed-76860442020-11-30 The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices Qiu, Haofeng Si, Zhangyong Luo, Yang Feng, Peipei Wu, Xujin Hou, Wenjia Zhu, Yabin Chan-Park, Mary B. Xu, Long Huang, Dongmei Front Bioeng Biotechnol Bioengineering and Biotechnology Medical device contamination caused by microbial pathogens such as bacteria and fungi has posed a severe threat to the patients’ health in hospitals. Due to the increasing resistance of pathogens to antibiotics, the efficacy of traditional antibiotics treatment is gradually decreasing for the infection treatment. Therefore, it is urgent to develop new antibacterial drugs to meet clinical or civilian needs. Antibacterial polymers have attracted the interests of researchers due to their unique bactericidal mechanism and excellent antibacterial effect. This article reviews the mechanism and advantages of antimicrobial polymers and the consideration for their translation. Their applications and advances in medical device surface coating were also reviewed. The information will provide a valuable reference to design and develop antibacterial devices that are resistant to pathogenic infections. Frontiers Media S.A. 2020-11-11 /pmc/articles/PMC7686044/ /pubmed/33262975 http://dx.doi.org/10.3389/fbioe.2020.00910 Text en Copyright © 2020 Qiu, Si, Luo, Feng, Wu, Hou, Zhu, Chan-Park, Xu and Huang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Qiu, Haofeng
Si, Zhangyong
Luo, Yang
Feng, Peipei
Wu, Xujin
Hou, Wenjia
Zhu, Yabin
Chan-Park, Mary B.
Xu, Long
Huang, Dongmei
The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices
title The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices
title_full The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices
title_fullStr The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices
title_full_unstemmed The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices
title_short The Mechanisms and the Applications of Antibacterial Polymers in Surface Modification on Medical Devices
title_sort mechanisms and the applications of antibacterial polymers in surface modification on medical devices
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686044/
https://www.ncbi.nlm.nih.gov/pubmed/33262975
http://dx.doi.org/10.3389/fbioe.2020.00910
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