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Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease

Human genetics provides unbiased insights into the causes of human disease, which can be used to create a foundation for effective ways to more accurately diagnose patients, stratify patients for more successful clinical trials, discover and develop new therapies, and ultimately help patients choose...

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Detalles Bibliográficos
Autor principal: Finkbeiner, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686089/
https://www.ncbi.nlm.nih.gov/pubmed/32977020
http://dx.doi.org/10.1016/j.nbd.2020.105088
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author Finkbeiner, Steven
author_facet Finkbeiner, Steven
author_sort Finkbeiner, Steven
collection PubMed
description Human genetics provides unbiased insights into the causes of human disease, which can be used to create a foundation for effective ways to more accurately diagnose patients, stratify patients for more successful clinical trials, discover and develop new therapies, and ultimately help patients choose the safest and most promising therapeutic option based on their risk profile. But the process for translating basic observations from human genetics studies into pathogenic disease mechanisms and treatments is laborious and complex, and this challenge has particularly slowed the development of interventions for neurodegenerative disease. In this review, we discuss the many steps in the process, the important considerations at each stage, and some of the latest tools and technologies that are available to help investigators translate insights from human genetics into diagnostic and therapeutic strategies that will lead to the sort of advances in clinical care that make a difference for patients.
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spelling pubmed-76860892021-12-01 Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease Finkbeiner, Steven Neurobiol Dis Article Human genetics provides unbiased insights into the causes of human disease, which can be used to create a foundation for effective ways to more accurately diagnose patients, stratify patients for more successful clinical trials, discover and develop new therapies, and ultimately help patients choose the safest and most promising therapeutic option based on their risk profile. But the process for translating basic observations from human genetics studies into pathogenic disease mechanisms and treatments is laborious and complex, and this challenge has particularly slowed the development of interventions for neurodegenerative disease. In this review, we discuss the many steps in the process, the important considerations at each stage, and some of the latest tools and technologies that are available to help investigators translate insights from human genetics into diagnostic and therapeutic strategies that will lead to the sort of advances in clinical care that make a difference for patients. 2020-09-23 2020-12 /pmc/articles/PMC7686089/ /pubmed/32977020 http://dx.doi.org/10.1016/j.nbd.2020.105088 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Finkbeiner, Steven
Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease
title Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease
title_full Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease
title_fullStr Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease
title_full_unstemmed Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease
title_short Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease
title_sort functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686089/
https://www.ncbi.nlm.nih.gov/pubmed/32977020
http://dx.doi.org/10.1016/j.nbd.2020.105088
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