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The role of NMR in leveraging dynamics and entropy in drug design
Nuclear Magnetic Resonance (NMR) spectroscopy has contributed to structure-based drug development (SBDD) in a unique way compared to the other biophysical methods. The potency of a ligand binding to a protein is dictated by the binding free energy, which is an intricate interplay between entropy and...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686249/ https://www.ncbi.nlm.nih.gov/pubmed/32720098 http://dx.doi.org/10.1007/s10858-020-00335-9 |