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The role of NMR in leveraging dynamics and entropy in drug design
Nuclear Magnetic Resonance (NMR) spectroscopy has contributed to structure-based drug development (SBDD) in a unique way compared to the other biophysical methods. The potency of a ligand binding to a protein is dictated by the binding free energy, which is an intricate interplay between entropy and...
Autores principales: | Dubey, Abhinav, Takeuchi, Koh, Reibarkh, Mikhail, Arthanari, Haribabu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686249/ https://www.ncbi.nlm.nih.gov/pubmed/32720098 http://dx.doi.org/10.1007/s10858-020-00335-9 |
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