S-nitrosylated and non-nitrosylated COX2 have differential expression and distinct subcellular localization in normal and breast cancer tissue

Immunohistochemical (IHC) staining in breast cancer shows both gain and loss of COX2 expression with disease risk and progression. We investigated four common COX2 antibody clones and found high specificity for purified human COX2 for three clones; however, recognition of COX2 in cell lysates was cl...

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Detalles Bibliográficos
Autores principales: Jindal, Sonali, Pennock, Nathan D., Klug, Alex, Narasimhan, Jayasri, Calhoun, Andrea, Roberts, Michelle R., Tamimi, Rulla M., Eliassen, A. Heather, Weinmann, Sheila, Borges, Virginia F., Schedin, Pepper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686348/
https://www.ncbi.nlm.nih.gov/pubmed/33298921
http://dx.doi.org/10.1038/s41523-020-00204-6

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