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The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study

Recent stroke studies have shown that the ipsi-lesional thalamus longitudinally and significantly decreases after stroke in the acute and subacute stages. However, additional considerations in the chronic stages of stroke require exploration including time since stroke, gender, intracortical volume,...

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Autores principales: Krishnamurthy, Lisa C., Champion, Gabriell N., McGregor, Keith M., Krishnamurthy, Venkatagiri, Turabi, Aaminah, Roberts, Simone R., Nocera, Joe R., Borich, Michael R., Rodriguez, Amy D., Belagaje, Samir R., Harrington, Rachael M., Harris-Love, Michelle L., Harnish, Stacy M., Drucker, Jonathan H., Benjamin, Michelle, Meadows, M. Lawson, Seeds, Lauren, Zlatar, Zvinka Z., Sudhyadhom, Atchar, Butler, Andrew J., Garcia, Amanda, Patten, Carolynn, Trinastic, Jonathan, Kautz, Steven A., Gregory, Chris, Crosson, Bruce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686360/
https://www.ncbi.nlm.nih.gov/pubmed/33235210
http://dx.doi.org/10.1038/s41598-020-76382-x
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author Krishnamurthy, Lisa C.
Champion, Gabriell N.
McGregor, Keith M.
Krishnamurthy, Venkatagiri
Turabi, Aaminah
Roberts, Simone R.
Nocera, Joe R.
Borich, Michael R.
Rodriguez, Amy D.
Belagaje, Samir R.
Harrington, Rachael M.
Harris-Love, Michelle L.
Harnish, Stacy M.
Drucker, Jonathan H.
Benjamin, Michelle
Meadows, M. Lawson
Seeds, Lauren
Zlatar, Zvinka Z.
Sudhyadhom, Atchar
Butler, Andrew J.
Garcia, Amanda
Patten, Carolynn
Trinastic, Jonathan
Kautz, Steven A.
Gregory, Chris
Crosson, Bruce A.
author_facet Krishnamurthy, Lisa C.
Champion, Gabriell N.
McGregor, Keith M.
Krishnamurthy, Venkatagiri
Turabi, Aaminah
Roberts, Simone R.
Nocera, Joe R.
Borich, Michael R.
Rodriguez, Amy D.
Belagaje, Samir R.
Harrington, Rachael M.
Harris-Love, Michelle L.
Harnish, Stacy M.
Drucker, Jonathan H.
Benjamin, Michelle
Meadows, M. Lawson
Seeds, Lauren
Zlatar, Zvinka Z.
Sudhyadhom, Atchar
Butler, Andrew J.
Garcia, Amanda
Patten, Carolynn
Trinastic, Jonathan
Kautz, Steven A.
Gregory, Chris
Crosson, Bruce A.
author_sort Krishnamurthy, Lisa C.
collection PubMed
description Recent stroke studies have shown that the ipsi-lesional thalamus longitudinally and significantly decreases after stroke in the acute and subacute stages. However, additional considerations in the chronic stages of stroke require exploration including time since stroke, gender, intracortical volume, aging, and lesion volume to better characterize thalamic differences after cortical infarct. This cross-sectional retrospective study quantified the ipsilesional and contralesional thalamus volume from 69 chronic stroke subjects’ anatomical MRI data (age 35–92) and related the thalamus volume to time since stroke, gender, intracortical volume, age, and lesion volume. The ipsi-lesional thalamus volume was significantly smaller than the contra-lesional thalamus volume (t(68) = 13.89, p < 0.0001). In the ipsilesional thalamus, significant effect for intracortical volume (t(68) = 2.76, p = 0.008), age (t(68) = 2.47, p = 0.02), lesion volume (t(68) = − 3.54, p = 0.0008), and age*time since stroke (t(68) = 2.46, p = 0.02) were identified. In the contralesional thalamus, significant effect for intracortical volume (t(68) = 3.2, p = 0.002) and age (t = − 3.17, p = 0.002) were identified. Clinical factors age and intracortical volume influence both ipsi- and contralesional thalamus volume and lesion volume influences the ipsilesional thalamus. Due to the cross-sectional nature of this study, additional research is warranted to understand differences in the neural circuitry and subsequent influence on volumetrics after stroke.
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spelling pubmed-76863602020-11-27 The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study Krishnamurthy, Lisa C. Champion, Gabriell N. McGregor, Keith M. Krishnamurthy, Venkatagiri Turabi, Aaminah Roberts, Simone R. Nocera, Joe R. Borich, Michael R. Rodriguez, Amy D. Belagaje, Samir R. Harrington, Rachael M. Harris-Love, Michelle L. Harnish, Stacy M. Drucker, Jonathan H. Benjamin, Michelle Meadows, M. Lawson Seeds, Lauren Zlatar, Zvinka Z. Sudhyadhom, Atchar Butler, Andrew J. Garcia, Amanda Patten, Carolynn Trinastic, Jonathan Kautz, Steven A. Gregory, Chris Crosson, Bruce A. Sci Rep Article Recent stroke studies have shown that the ipsi-lesional thalamus longitudinally and significantly decreases after stroke in the acute and subacute stages. However, additional considerations in the chronic stages of stroke require exploration including time since stroke, gender, intracortical volume, aging, and lesion volume to better characterize thalamic differences after cortical infarct. This cross-sectional retrospective study quantified the ipsilesional and contralesional thalamus volume from 69 chronic stroke subjects’ anatomical MRI data (age 35–92) and related the thalamus volume to time since stroke, gender, intracortical volume, age, and lesion volume. The ipsi-lesional thalamus volume was significantly smaller than the contra-lesional thalamus volume (t(68) = 13.89, p < 0.0001). In the ipsilesional thalamus, significant effect for intracortical volume (t(68) = 2.76, p = 0.008), age (t(68) = 2.47, p = 0.02), lesion volume (t(68) = − 3.54, p = 0.0008), and age*time since stroke (t(68) = 2.46, p = 0.02) were identified. In the contralesional thalamus, significant effect for intracortical volume (t(68) = 3.2, p = 0.002) and age (t = − 3.17, p = 0.002) were identified. Clinical factors age and intracortical volume influence both ipsi- and contralesional thalamus volume and lesion volume influences the ipsilesional thalamus. Due to the cross-sectional nature of this study, additional research is warranted to understand differences in the neural circuitry and subsequent influence on volumetrics after stroke. Nature Publishing Group UK 2020-11-24 /pmc/articles/PMC7686360/ /pubmed/33235210 http://dx.doi.org/10.1038/s41598-020-76382-x Text en © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Krishnamurthy, Lisa C.
Champion, Gabriell N.
McGregor, Keith M.
Krishnamurthy, Venkatagiri
Turabi, Aaminah
Roberts, Simone R.
Nocera, Joe R.
Borich, Michael R.
Rodriguez, Amy D.
Belagaje, Samir R.
Harrington, Rachael M.
Harris-Love, Michelle L.
Harnish, Stacy M.
Drucker, Jonathan H.
Benjamin, Michelle
Meadows, M. Lawson
Seeds, Lauren
Zlatar, Zvinka Z.
Sudhyadhom, Atchar
Butler, Andrew J.
Garcia, Amanda
Patten, Carolynn
Trinastic, Jonathan
Kautz, Steven A.
Gregory, Chris
Crosson, Bruce A.
The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study
title The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study
title_full The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study
title_fullStr The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study
title_full_unstemmed The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study
title_short The effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study
title_sort effect of time since stroke, gender, age, and lesion size on thalamus volume in chronic stroke: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686360/
https://www.ncbi.nlm.nih.gov/pubmed/33235210
http://dx.doi.org/10.1038/s41598-020-76382-x
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