Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals

Genome-wide DNA demethylation is a unique feature of mammalian development and naïve pluripotent stem cells. Here, we describe a recently evolved pathway in which global hypomethylation is achieved by the coupling of active and passive demethylation. TET activity is required, albeit indirectly, for...

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Detalles Bibliográficos
Autores principales: Mulholland, Christopher B., Nishiyama, Atsuya, Ryan, Joel, Nakamura, Ryohei, Yiğit, Merve, Glück, Ivo M., Trummer, Carina, Qin, Weihua, Bartoschek, Michael D., Traube, Franziska R., Parsa, Edris, Ugur, Enes, Modic, Miha, Acharya, Aishwarya, Stolz, Paul, Ziegenhain, Christoph, Wierer, Michael, Enard, Wolfgang, Carell, Thomas, Lamb, Don C., Takeda, Hiroyuki, Nakanashi, Makoto, Bultmann, Sebastian, Leonhardt, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686362/
https://www.ncbi.nlm.nih.gov/pubmed/33235224
http://dx.doi.org/10.1038/s41467-020-19603-1

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