Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice

The abuse potential of ketamine limits its clinical application, but the precise mechanism remains largely unclear. Here we discovered that ketamine significantly remodels the endocannabinoid-related lipidome and activates 2-arachidonoylglycerol (2-AG) signaling in the dorsal striatum (caudate nucle...

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Detalles Bibliográficos
Autores principales: Xu, Wei, Li, Hongchun, Wang, Liang, Zhang, Jiamei, Liu, Chunqi, Wan, Xuemei, Liu, Xiaochong, Hu, Yiming, Fang, Qiyao, Xiao, Yuanyuan, Bu, Qian, Wang, Hongbo, Tian, Jingwei, Zhao, Yinglan, Cen, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686380/
https://www.ncbi.nlm.nih.gov/pubmed/33235205
http://dx.doi.org/10.1038/s41467-020-19780-z

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