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Antiviral Effects of Oleandrin

Over the past 15 years, investigators have reported on the utility and safety of cardiac glycosides for numerous health benefits including those as treatments for malignant disease, stroke-mediated ischemic injury and certain neurodegenerative diseases. In addition to those, there is a growing body...

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Autores principales: Newman, Robert A, Sastry, K Jagannadha, Arav-Boger, Ravit, Cai, Hongyi, Matos, Rick, Harrod, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686471/
https://www.ncbi.nlm.nih.gov/pubmed/33262663
http://dx.doi.org/10.2147/JEP.S273120
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author Newman, Robert A
Sastry, K Jagannadha
Arav-Boger, Ravit
Cai, Hongyi
Matos, Rick
Harrod, Robert
author_facet Newman, Robert A
Sastry, K Jagannadha
Arav-Boger, Ravit
Cai, Hongyi
Matos, Rick
Harrod, Robert
author_sort Newman, Robert A
collection PubMed
description Over the past 15 years, investigators have reported on the utility and safety of cardiac glycosides for numerous health benefits including those as treatments for malignant disease, stroke-mediated ischemic injury and certain neurodegenerative diseases. In addition to those, there is a growing body of evidence for novel antiviral effects of selected cardiac glycoside molecules. One unique cardiac glycoside, oleandrin derived from Nerium oleander, has been reported to have antiviral activity specifically against ‘enveloped’ viruses including HIV and HTLV-1. Importantly, a recent publication has presented in vitro evidence for oleandrin’s ability to inhibit production of infectious virus particles when used for treatment prior to, as well as after infection by SARS-CoV-2/COVID-19. This review will highlight the known in vitro antiviral effects of oleandrin as well as present previously unpublished effects of this novel cardiac glycoside against Ebola virus, Cytomegalovirus, and Herpes simplex viruses.
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spelling pubmed-76864712020-11-30 Antiviral Effects of Oleandrin Newman, Robert A Sastry, K Jagannadha Arav-Boger, Ravit Cai, Hongyi Matos, Rick Harrod, Robert J Exp Pharmacol Review Over the past 15 years, investigators have reported on the utility and safety of cardiac glycosides for numerous health benefits including those as treatments for malignant disease, stroke-mediated ischemic injury and certain neurodegenerative diseases. In addition to those, there is a growing body of evidence for novel antiviral effects of selected cardiac glycoside molecules. One unique cardiac glycoside, oleandrin derived from Nerium oleander, has been reported to have antiviral activity specifically against ‘enveloped’ viruses including HIV and HTLV-1. Importantly, a recent publication has presented in vitro evidence for oleandrin’s ability to inhibit production of infectious virus particles when used for treatment prior to, as well as after infection by SARS-CoV-2/COVID-19. This review will highlight the known in vitro antiviral effects of oleandrin as well as present previously unpublished effects of this novel cardiac glycoside against Ebola virus, Cytomegalovirus, and Herpes simplex viruses. Dove 2020-11-16 /pmc/articles/PMC7686471/ /pubmed/33262663 http://dx.doi.org/10.2147/JEP.S273120 Text en © 2020 Newman et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Newman, Robert A
Sastry, K Jagannadha
Arav-Boger, Ravit
Cai, Hongyi
Matos, Rick
Harrod, Robert
Antiviral Effects of Oleandrin
title Antiviral Effects of Oleandrin
title_full Antiviral Effects of Oleandrin
title_fullStr Antiviral Effects of Oleandrin
title_full_unstemmed Antiviral Effects of Oleandrin
title_short Antiviral Effects of Oleandrin
title_sort antiviral effects of oleandrin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686471/
https://www.ncbi.nlm.nih.gov/pubmed/33262663
http://dx.doi.org/10.2147/JEP.S273120
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