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Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens
Practically applied techniques for ultrasonic biomedical imaging employ delay-and-sum (DAS) beamforming which can resolve two objects down to 2.1λ within the acoustic Fresnel zone. Here, we demonstrate a phononic metamaterial lens (ML) for detection of laterally subwavelength object features in tiss...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686495/ https://www.ncbi.nlm.nih.gov/pubmed/33235277 http://dx.doi.org/10.1038/s41467-020-19591-2 |
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author | Walker, Ezekiel L. Jin, Yuqi Reyes, Delfino Neogi, Arup |
author_facet | Walker, Ezekiel L. Jin, Yuqi Reyes, Delfino Neogi, Arup |
author_sort | Walker, Ezekiel L. |
collection | PubMed |
description | Practically applied techniques for ultrasonic biomedical imaging employ delay-and-sum (DAS) beamforming which can resolve two objects down to 2.1λ within the acoustic Fresnel zone. Here, we demonstrate a phononic metamaterial lens (ML) for detection of laterally subwavelength object features in tissue-like phantoms beyond the phononic crystal evanescent zone and Fresnel zone of the emitter. The ML produces metamaterial collimation that spreads 8x less than the emitting transducer. Utilizing collimation, 3.6x greater lateral resolution beyond the Fresnel zone limit was achieved. Both hard objects and tissue approximating masses were examined in gelatin tissue phantoms near the Fresnel zone limit. Lateral dimensions and separation were resolved down to 0.50λ for hard objects, with tissue approximating masses slightly higher at 0.73λ. The work represents the application of a metamaterial for spatial characterization, and subwavelength resolution in a biosystem beyond the Fresnel zone limit. |
format | Online Article Text |
id | pubmed-7686495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76864952020-12-03 Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens Walker, Ezekiel L. Jin, Yuqi Reyes, Delfino Neogi, Arup Nat Commun Article Practically applied techniques for ultrasonic biomedical imaging employ delay-and-sum (DAS) beamforming which can resolve two objects down to 2.1λ within the acoustic Fresnel zone. Here, we demonstrate a phononic metamaterial lens (ML) for detection of laterally subwavelength object features in tissue-like phantoms beyond the phononic crystal evanescent zone and Fresnel zone of the emitter. The ML produces metamaterial collimation that spreads 8x less than the emitting transducer. Utilizing collimation, 3.6x greater lateral resolution beyond the Fresnel zone limit was achieved. Both hard objects and tissue approximating masses were examined in gelatin tissue phantoms near the Fresnel zone limit. Lateral dimensions and separation were resolved down to 0.50λ for hard objects, with tissue approximating masses slightly higher at 0.73λ. The work represents the application of a metamaterial for spatial characterization, and subwavelength resolution in a biosystem beyond the Fresnel zone limit. Nature Publishing Group UK 2020-11-24 /pmc/articles/PMC7686495/ /pubmed/33235277 http://dx.doi.org/10.1038/s41467-020-19591-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Walker, Ezekiel L. Jin, Yuqi Reyes, Delfino Neogi, Arup Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens |
title | Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens |
title_full | Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens |
title_fullStr | Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens |
title_full_unstemmed | Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens |
title_short | Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens |
title_sort | sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686495/ https://www.ncbi.nlm.nih.gov/pubmed/33235277 http://dx.doi.org/10.1038/s41467-020-19591-2 |
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