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Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens

Practically applied techniques for ultrasonic biomedical imaging employ delay-and-sum (DAS) beamforming which can resolve two objects down to 2.1λ within the acoustic Fresnel zone. Here, we demonstrate a phononic metamaterial lens (ML) for detection of laterally subwavelength object features in tiss...

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Detalles Bibliográficos
Autores principales: Walker, Ezekiel L., Jin, Yuqi, Reyes, Delfino, Neogi, Arup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686495/
https://www.ncbi.nlm.nih.gov/pubmed/33235277
http://dx.doi.org/10.1038/s41467-020-19591-2
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author Walker, Ezekiel L.
Jin, Yuqi
Reyes, Delfino
Neogi, Arup
author_facet Walker, Ezekiel L.
Jin, Yuqi
Reyes, Delfino
Neogi, Arup
author_sort Walker, Ezekiel L.
collection PubMed
description Practically applied techniques for ultrasonic biomedical imaging employ delay-and-sum (DAS) beamforming which can resolve two objects down to 2.1λ within the acoustic Fresnel zone. Here, we demonstrate a phononic metamaterial lens (ML) for detection of laterally subwavelength object features in tissue-like phantoms beyond the phononic crystal evanescent zone and Fresnel zone of the emitter. The ML produces metamaterial collimation that spreads 8x less than the emitting transducer. Utilizing collimation, 3.6x greater lateral resolution beyond the Fresnel zone limit was achieved. Both hard objects and tissue approximating masses were examined in gelatin tissue phantoms near the Fresnel zone limit. Lateral dimensions and separation were resolved down to 0.50λ for hard objects, with tissue approximating masses slightly higher at 0.73λ. The work represents the application of a metamaterial for spatial characterization, and subwavelength resolution in a biosystem beyond the Fresnel zone limit.
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spelling pubmed-76864952020-12-03 Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens Walker, Ezekiel L. Jin, Yuqi Reyes, Delfino Neogi, Arup Nat Commun Article Practically applied techniques for ultrasonic biomedical imaging employ delay-and-sum (DAS) beamforming which can resolve two objects down to 2.1λ within the acoustic Fresnel zone. Here, we demonstrate a phononic metamaterial lens (ML) for detection of laterally subwavelength object features in tissue-like phantoms beyond the phononic crystal evanescent zone and Fresnel zone of the emitter. The ML produces metamaterial collimation that spreads 8x less than the emitting transducer. Utilizing collimation, 3.6x greater lateral resolution beyond the Fresnel zone limit was achieved. Both hard objects and tissue approximating masses were examined in gelatin tissue phantoms near the Fresnel zone limit. Lateral dimensions and separation were resolved down to 0.50λ for hard objects, with tissue approximating masses slightly higher at 0.73λ. The work represents the application of a metamaterial for spatial characterization, and subwavelength resolution in a biosystem beyond the Fresnel zone limit. Nature Publishing Group UK 2020-11-24 /pmc/articles/PMC7686495/ /pubmed/33235277 http://dx.doi.org/10.1038/s41467-020-19591-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Walker, Ezekiel L.
Jin, Yuqi
Reyes, Delfino
Neogi, Arup
Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens
title Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens
title_full Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens
title_fullStr Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens
title_full_unstemmed Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens
title_short Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens
title_sort sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686495/
https://www.ncbi.nlm.nih.gov/pubmed/33235277
http://dx.doi.org/10.1038/s41467-020-19591-2
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