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Genkwadaphnin inhibits growth and invasion in hepatocellular carcinoma by blocking DHCR24-mediated cholesterol biosynthesis and lipid rafts formation

BACKGROUND: The liver is the central organ for cholesterol homoeostasis, and its dysfunction might cause liver pathological alterations including hepatocellular carcinomas (HCCs). 3β-hydroxysteroid-Δ24 reductase (DHCR24), a crucial enzyme of cholesterol biosynthetic pathway, is involved in lipid raf...

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Detalles Bibliográficos
Autores principales:	Wu, Jie, Guo, Ling, Qiu, Xiaoran, Ren, Yong, Li, Feifei, Cui, Wei, Song, Shaojiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686505/ https://www.ncbi.nlm.nih.gov/pubmed/32958824 http://dx.doi.org/10.1038/s41416-020-01085-z

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