Cargando…

Genkwadaphnin inhibits growth and invasion in hepatocellular carcinoma by blocking DHCR24-mediated cholesterol biosynthesis and lipid rafts formation

BACKGROUND: The liver is the central organ for cholesterol homoeostasis, and its dysfunction might cause liver pathological alterations including hepatocellular carcinomas (HCCs). 3β-hydroxysteroid-Δ24 reductase (DHCR24), a crucial enzyme of cholesterol biosynthetic pathway, is involved in lipid raf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Jie, Guo, Ling, Qiu, Xiaoran, Ren, Yong, Li, Feifei, Cui, Wei, Song, Shaojiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686505/ https://www.ncbi.nlm.nih.gov/pubmed/32958824 http://dx.doi.org/10.1038/s41416-020-01085-z

Ejemplares similares

DPP4 Regulates DHCR24-Mediated Cholesterol Biosynthesis to Promote Methotrexate Resistance in Gestational Trophoblastic Neoplastic Cells
por: Yuan, Weijie, et al.
Publicado: (2021)

Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24(−/−) Mice
por: Kuehnle, Katrin, et al.
Publicado: (2009)

Oncogenic role of the SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2(+) diffuse large B-cell lymphomas
por: Shen, Yajie, et al.
Publicado: (2022)

Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma
por: Dai, Miao, et al.
Publicado: (2017)

Key Molecular Requirements for Raft Formation in Lipid/Cholesterol Membranes
por: Hakobyan, Davit, et al.
Publicado: (2014)

The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis
por: Bai, Xiaojing, et al.
Publicado: (2022)

Virtual Screening of Novel 24-Dehydroxysterol Reductase (DHCR24) Inhibitors and the Biological Evaluation of Irbesartan in Cholesterol-Lowering Effect
por: Wang, Haozhen, et al.
Publicado: (2023)

Development of Serum DHCR24 Antibody as a Marker for Hepatocellular Carcinoma: The End of the Beginning
por: Chan, Stephen L., et al.
Publicado: (2015)

RETRACTED ARTICLE: Age-dependent Increase in Desmosterol Restores DRM Formation and Membrane-related Functions in Cholesterol-free DHCR24(−/−) Mice
por: Kuehnle, Katrin, et al.
Publicado: (2008)

Cellular cholesterol loss by DHCR24 knockdown leads to Aβ production by changing APP intracellular localization
por: Huang, Yue, et al.
Publicado: (2023)

Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer
por: Chen, Yuqi, et al.
Publicado: (2023)

Seladin-1/DHCR24 protects neuroblastoma cells against Aβ toxicity by increasing membrane cholesterol content
por: Cecchi, C, et al.
Publicado: (2008)

Selective reconstitution of liver cholesterol biosynthesis promotes lung maturation but does not prevent neonatal lethality in Dhcr7 null mice
por: Yu, Hongwei, et al.
Publicado: (2007)

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
por: Martiskainen, Henna, et al.
Publicado: (2017)

DHCR24, a Key Enzyme of Cholesterol Synthesis, Serves as a Marker Gene of the Mouse Adrenal Gland Inner Cortex
por: Zheng, Huifei Sophia, et al.
Publicado: (2023)

Identification and Characterization of 24-Dehydrocholesterol Reductase (DHCR24) in the Two-Spotted Cricket, Gryllus bimaculatus
por: Mack, Yin Shan Isa, et al.
Publicado: (2021)

Disruption of Dhcr7 and Insig1/2 in cholesterol metabolism causes defects in bone formation and homeostasis through primary cilium formation
por: Suzuki, Akiko, et al.
Publicado: (2020)

Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation
por: Zhou, Enchen, et al.
Publicado: (2023)

Intermolecular interaction of phosphatidylinositol with the lipid raft molecules sphingomyelin and cholesterol
por: Kinoshita, Masanao, et al.
Publicado: (2008)

Cholesterol and Sphingolipid Enriched Lipid Rafts as Therapeutic Targets in Cancer
por: Codini, Michela, et al.
Publicado: (2021)

OR19-1 Ncor1 Regulates the Expression of Dhcr24, which Controls de novo Cholesterol Synthesis in the Adrenal Gland Inner Cortex
por: Huang, Chen-Che Jeff, et al.
Publicado: (2022)

DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice
por: Zhang, Wen-bin, et al.
Publicado: (2023)

Raft Formation in Lipid Bilayers Coupled to Curvature
por: Sadeghi, Sina, et al.
Publicado: (2014)

Serum DHCR24 Auto-antibody as a new Biomarker for Progression of Hepatitis C
por: Ezzikouri, Sayeh, et al.
Publicado: (2015)

Lipid Rafts and Redox Regulation of Cellular Signaling in Cholesterol Induced Atherosclerosis
por: Catalgol, Betul, et al.
Publicado: (2010)

Association of lipid rafts cholesterol with clinical profile in fragile X syndrome
por: Toupin, Amanda, et al.
Publicado: (2022)

Genkwadaphnin Induces IFN-γ via PKD1/NF-κB/STAT1 Dependent Pathway in NK-92 Cells
por: Kang, Ho-Bum, et al.
Publicado: (2014)

ODP037 Effects of DHCR24 Inhibitor on Excessive Adrenal Steroidogenesis in db/db mouse
por: Kamigaki, Risa, et al.
Publicado: (2022)

SAT040 Administration Of A DHCR24 Inhibitor Reduces The Excessive Adrenal Steroidogenesis In db/db Mice Through Effects The Alteration Of Intracellular Cholesterol Metabolism
por: Kamigaki, Risa, et al.
Publicado: (2023)

Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?
por: Vona, Rosa, et al.
Publicado: (2021)

Cholesterol-Rich Lipid Rafts as Platforms for SARS-CoV-2 Entry
por: Palacios-Rápalo, Selvin Noé, et al.
Publicado: (2021)

Modulating cholesterol-rich lipid rafts to disrupt influenza A virus infection
por: Li, Yu-Jyun, et al.
Publicado: (2022)

Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts
por: Chiu, Po-Lin, et al.
Publicado: (2023)

DHCR24 Knockdown Induces Tau Hyperphosphorylation at Thr181, Ser199, Ser262, and Ser396 Sites via Activation of the Lipid Raft-Dependent Ras/MEK/ERK Signaling Pathway in C8D1A Astrocytes
por: Mai, Meiting, et al.
Publicado: (2022)

DHCR24 predicts poor clinicopathological features of patients with bladder cancer: A STROBE-compliant study
por: Liu, Xiao-Ping, et al.
Publicado: (2018)

Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains
por: Cho, Yoon Young, et al.
Publicado: (2020)

RaftProt: mammalian lipid raft proteome database
por: Shah, Anup, et al.
Publicado: (2014)

Neuronal Differentiation of Rat Hair Follicle Stem Cells: the Involvement of the Neuroprotective Factor Seladin-1 (DHCR24)
por: Gilanchi, Samira, et al.
Publicado: (2014)

Dhcr24 activates the PI3K/Akt/HKII pathway and protects against dilated cardiomyopathy in mice
por: Dong, Wei, et al.
Publicado: (2018)

Cholesterol‐enriched membrane rafts and insulin secretion
por: Dirkx Jr, Ronald, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_pnioer9kraokfv394qpqtcv9ll