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Discovery of Novel IDH1 Inhibitor Through Comparative Structure-Based Virtual Screening

IDH1 mutations occur in about 20–30% of gliomas and are a promising target for the treatment of cancer. In the present study, the performance of aIDH1(R132H) was verified via glide-docking-based virtual screening. On the basis of the two crystal structures (5TQH and 6B0Z) with the best discriminatin...

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Detalles Bibliográficos
Autores principales:	Wang, Yuwei, Tang, Shuai, Lai, Huanling, Jin, Ruyi, Long, Xu, Li, Na, Tang, Yuping, Guo, Hui, Yao, Xiaojun, Leung, Elaine Lai-Han
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686577/ https://www.ncbi.nlm.nih.gov/pubmed/33262701 http://dx.doi.org/10.3389/fphar.2020.579768

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