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Effects of Sleep Deprivation on the Tryptophan Metabolism
Sleep has a regulatory role in maintaining metabolic homeostasis and cellular functions. Inadequate sleep time and sleep disorders have become more prevalent in the modern lifestyle. Fragmentation of sleep pattern alters critical intracellular second messengers and neurotransmitters which have key f...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686593/ https://www.ncbi.nlm.nih.gov/pubmed/33281456 http://dx.doi.org/10.1177/1178646920970902 |
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author | Bhat, Abid Pires, Ananda Staats Tan, Vanessa Babu Chidambaram, Saravana Guillemin, Gilles J |
author_facet | Bhat, Abid Pires, Ananda Staats Tan, Vanessa Babu Chidambaram, Saravana Guillemin, Gilles J |
author_sort | Bhat, Abid |
collection | PubMed |
description | Sleep has a regulatory role in maintaining metabolic homeostasis and cellular functions. Inadequate sleep time and sleep disorders have become more prevalent in the modern lifestyle. Fragmentation of sleep pattern alters critical intracellular second messengers and neurotransmitters which have key functions in brain development and behavioral functions. Tryptophan metabolism has also been found to get altered in SD and it is linked to various neurodegenerative diseases. The kynurenine pathway is a major regulator of the immune response. Adequate sleep alleviates neuroinflammation and facilitates the cellular clearance of metabolic toxins produced within the brain, while sleep deprivation activates the enzymatic degradation of tryptophan via the kynurenine pathway, which results in an increased accumulation of neurotoxic metabolites. SD causes increased production and accumulation of kynurenic acid in various regions of the brain. Higher levels of kynurenic acid have been found to trigger apoptosis, leads to cognitive decline, and inhibit neurogenesis. This review aims to link the impact of sleep deprivation on tryptophan metabolism and associated complication in the brain. |
format | Online Article Text |
id | pubmed-7686593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-76865932020-12-03 Effects of Sleep Deprivation on the Tryptophan Metabolism Bhat, Abid Pires, Ananda Staats Tan, Vanessa Babu Chidambaram, Saravana Guillemin, Gilles J Int J Tryptophan Res Review Sleep has a regulatory role in maintaining metabolic homeostasis and cellular functions. Inadequate sleep time and sleep disorders have become more prevalent in the modern lifestyle. Fragmentation of sleep pattern alters critical intracellular second messengers and neurotransmitters which have key functions in brain development and behavioral functions. Tryptophan metabolism has also been found to get altered in SD and it is linked to various neurodegenerative diseases. The kynurenine pathway is a major regulator of the immune response. Adequate sleep alleviates neuroinflammation and facilitates the cellular clearance of metabolic toxins produced within the brain, while sleep deprivation activates the enzymatic degradation of tryptophan via the kynurenine pathway, which results in an increased accumulation of neurotoxic metabolites. SD causes increased production and accumulation of kynurenic acid in various regions of the brain. Higher levels of kynurenic acid have been found to trigger apoptosis, leads to cognitive decline, and inhibit neurogenesis. This review aims to link the impact of sleep deprivation on tryptophan metabolism and associated complication in the brain. SAGE Publications 2020-11-23 /pmc/articles/PMC7686593/ /pubmed/33281456 http://dx.doi.org/10.1177/1178646920970902 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Bhat, Abid Pires, Ananda Staats Tan, Vanessa Babu Chidambaram, Saravana Guillemin, Gilles J Effects of Sleep Deprivation on the Tryptophan Metabolism |
title | Effects of Sleep Deprivation on the Tryptophan
Metabolism |
title_full | Effects of Sleep Deprivation on the Tryptophan
Metabolism |
title_fullStr | Effects of Sleep Deprivation on the Tryptophan
Metabolism |
title_full_unstemmed | Effects of Sleep Deprivation on the Tryptophan
Metabolism |
title_short | Effects of Sleep Deprivation on the Tryptophan
Metabolism |
title_sort | effects of sleep deprivation on the tryptophan
metabolism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686593/ https://www.ncbi.nlm.nih.gov/pubmed/33281456 http://dx.doi.org/10.1177/1178646920970902 |
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