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Clinical and Biochemical Characteristics of Dengue Infections in Children From Sri Lanka

INTRODUCTION: Analyzing dengue disease patterns from different parts of the world should help us formulate more evidence based treatment guidelines and appropriately allocate limited healthcare resources. Therefore, we described the disease characteristics of hospitalised pediatric patients with den...

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Autores principales: Jayarajah, Umesh, Madarasinghe, Manohari, Hapugoda, Damayanthi, Dissanayake, Upul, Perera, Lakshika, Kannangara, Vibhavee, Udayangani, Champika, Peiris, Ranga, Yasawardene, Pamodh, De Zoysa, Ishan, Seneviratne, Suranjith L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686613/
https://www.ncbi.nlm.nih.gov/pubmed/33283028
http://dx.doi.org/10.1177/2333794X20974207
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author Jayarajah, Umesh
Madarasinghe, Manohari
Hapugoda, Damayanthi
Dissanayake, Upul
Perera, Lakshika
Kannangara, Vibhavee
Udayangani, Champika
Peiris, Ranga
Yasawardene, Pamodh
De Zoysa, Ishan
Seneviratne, Suranjith L.
author_facet Jayarajah, Umesh
Madarasinghe, Manohari
Hapugoda, Damayanthi
Dissanayake, Upul
Perera, Lakshika
Kannangara, Vibhavee
Udayangani, Champika
Peiris, Ranga
Yasawardene, Pamodh
De Zoysa, Ishan
Seneviratne, Suranjith L.
author_sort Jayarajah, Umesh
collection PubMed
description INTRODUCTION: Analyzing dengue disease patterns from different parts of the world should help us formulate more evidence based treatment guidelines and appropriately allocate limited healthcare resources. Therefore, we described the disease characteristics of hospitalised pediatric patients with dengue infections from Sri Lanka during the 2017 dengue epidemic. METHODS: Clinical and biochemical characteristics of pediatric dengue patients treated at a secondary care hospital in Sri Lanka from 1 June 2017 to 31 August 2017 were analyzed. Our findings were compared with previous pediatric dengue studies in Asia. RESULTS: A TOTAL OF 305: patients (number of males = 184(60%); mean age = 8.6 years) were analyzed. DF (Dengue Fever)—245 (80.3%), DHF (Dengue Hemorrhagic fever)—I:52 (17%), DHF—II:7 (2.3%), and DHF—III:1 (0.3%). Significant associations were found between DHF and abdominal symptoms/signs and overt bleeding manifestations (P < .001). Time of onset of the critical phase was variable (Day 3: 12%, Day 4-5: 78%, Day 6: 5%, and Day 7: 5%). Platelet and white-cell counts (WBC) were significantly lower in DHF than DF; liver enzyme derangement was mild and was similar in the DHF and DF subgroups. None had cardiac, renal, or neurological manifestations and all recovered uneventfully. CONCLUSION: In Sri Lankan pediatric dengue patients, we found abdominal symptoms and signs, decreased WBC and platelet counts and bleeding manifestations were to be significantly associated with DHF. Liver enzyme derangement did not predict DHF. The time of onset of the critical phase was difficult to predict due to the considerable variations noted.
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spelling pubmed-76866132020-12-03 Clinical and Biochemical Characteristics of Dengue Infections in Children From Sri Lanka Jayarajah, Umesh Madarasinghe, Manohari Hapugoda, Damayanthi Dissanayake, Upul Perera, Lakshika Kannangara, Vibhavee Udayangani, Champika Peiris, Ranga Yasawardene, Pamodh De Zoysa, Ishan Seneviratne, Suranjith L. Glob Pediatr Health Original Article INTRODUCTION: Analyzing dengue disease patterns from different parts of the world should help us formulate more evidence based treatment guidelines and appropriately allocate limited healthcare resources. Therefore, we described the disease characteristics of hospitalised pediatric patients with dengue infections from Sri Lanka during the 2017 dengue epidemic. METHODS: Clinical and biochemical characteristics of pediatric dengue patients treated at a secondary care hospital in Sri Lanka from 1 June 2017 to 31 August 2017 were analyzed. Our findings were compared with previous pediatric dengue studies in Asia. RESULTS: A TOTAL OF 305: patients (number of males = 184(60%); mean age = 8.6 years) were analyzed. DF (Dengue Fever)—245 (80.3%), DHF (Dengue Hemorrhagic fever)—I:52 (17%), DHF—II:7 (2.3%), and DHF—III:1 (0.3%). Significant associations were found between DHF and abdominal symptoms/signs and overt bleeding manifestations (P < .001). Time of onset of the critical phase was variable (Day 3: 12%, Day 4-5: 78%, Day 6: 5%, and Day 7: 5%). Platelet and white-cell counts (WBC) were significantly lower in DHF than DF; liver enzyme derangement was mild and was similar in the DHF and DF subgroups. None had cardiac, renal, or neurological manifestations and all recovered uneventfully. CONCLUSION: In Sri Lankan pediatric dengue patients, we found abdominal symptoms and signs, decreased WBC and platelet counts and bleeding manifestations were to be significantly associated with DHF. Liver enzyme derangement did not predict DHF. The time of onset of the critical phase was difficult to predict due to the considerable variations noted. SAGE Publications 2020-11-22 /pmc/articles/PMC7686613/ /pubmed/33283028 http://dx.doi.org/10.1177/2333794X20974207 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Jayarajah, Umesh
Madarasinghe, Manohari
Hapugoda, Damayanthi
Dissanayake, Upul
Perera, Lakshika
Kannangara, Vibhavee
Udayangani, Champika
Peiris, Ranga
Yasawardene, Pamodh
De Zoysa, Ishan
Seneviratne, Suranjith L.
Clinical and Biochemical Characteristics of Dengue Infections in Children From Sri Lanka
title Clinical and Biochemical Characteristics of Dengue Infections in Children From Sri Lanka
title_full Clinical and Biochemical Characteristics of Dengue Infections in Children From Sri Lanka
title_fullStr Clinical and Biochemical Characteristics of Dengue Infections in Children From Sri Lanka
title_full_unstemmed Clinical and Biochemical Characteristics of Dengue Infections in Children From Sri Lanka
title_short Clinical and Biochemical Characteristics of Dengue Infections in Children From Sri Lanka
title_sort clinical and biochemical characteristics of dengue infections in children from sri lanka
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686613/
https://www.ncbi.nlm.nih.gov/pubmed/33283028
http://dx.doi.org/10.1177/2333794X20974207
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