Posaconazole aggravates vincristine-related hypertension in children with acute lymphoblastic leukemia: a case report

Vincristine-related secondary hypertension is rare. This study reports two children who were treated with vincristine for acute lymphoblastic leukemia (ALL) and posaconazole for fungal infections who experienced vincristine-related secondary hypertension. Blood pressure normalized in both children a...

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Detalles Bibliográficos
Autores principales: Lin, Chao, Chen, Guohua, Huang, Junbin, Cheng, Yucai, Xu, Yahong, Zhang, Airun, Xue, Hongman, Chen, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686620/
https://www.ncbi.nlm.nih.gov/pubmed/33213238
http://dx.doi.org/10.1177/0300060520969579
Descripción
Sumario:Vincristine-related secondary hypertension is rare. This study reports two children who were treated with vincristine for acute lymphoblastic leukemia (ALL) and posaconazole for fungal infections who experienced vincristine-related secondary hypertension. Blood pressure normalized in both children after halting the drugs and providing antihypertensive treatment. Thus, posaconazole can interact with vincristine and induce secondary hypertension in children with ALL. As an adverse event, this interaction is a rare occurrence.

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