Posaconazole aggravates vincristine-related hypertension in children with acute lymphoblastic leukemia: a case report

Vincristine-related secondary hypertension is rare. This study reports two children who were treated with vincristine for acute lymphoblastic leukemia (ALL) and posaconazole for fungal infections who experienced vincristine-related secondary hypertension. Blood pressure normalized in both children a...

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Detalles Bibliográficos
Autores principales: Lin, Chao, Chen, Guohua, Huang, Junbin, Cheng, Yucai, Xu, Yahong, Zhang, Airun, Xue, Hongman, Chen, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686620/
https://www.ncbi.nlm.nih.gov/pubmed/33213238
http://dx.doi.org/10.1177/0300060520969579
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author Lin, Chao
Chen, Guohua
Huang, Junbin
Cheng, Yucai
Xu, Yahong
Zhang, Airun
Xue, Hongman
Chen, Chun
author_facet Lin, Chao
Chen, Guohua
Huang, Junbin
Cheng, Yucai
Xu, Yahong
Zhang, Airun
Xue, Hongman
Chen, Chun
author_sort Lin, Chao
collection PubMed
description Vincristine-related secondary hypertension is rare. This study reports two children who were treated with vincristine for acute lymphoblastic leukemia (ALL) and posaconazole for fungal infections who experienced vincristine-related secondary hypertension. Blood pressure normalized in both children after halting the drugs and providing antihypertensive treatment. Thus, posaconazole can interact with vincristine and induce secondary hypertension in children with ALL. As an adverse event, this interaction is a rare occurrence.
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spelling pubmed-76866202020-12-03 Posaconazole aggravates vincristine-related hypertension in children with acute lymphoblastic leukemia: a case report Lin, Chao Chen, Guohua Huang, Junbin Cheng, Yucai Xu, Yahong Zhang, Airun Xue, Hongman Chen, Chun J Int Med Res Case Report Vincristine-related secondary hypertension is rare. This study reports two children who were treated with vincristine for acute lymphoblastic leukemia (ALL) and posaconazole for fungal infections who experienced vincristine-related secondary hypertension. Blood pressure normalized in both children after halting the drugs and providing antihypertensive treatment. Thus, posaconazole can interact with vincristine and induce secondary hypertension in children with ALL. As an adverse event, this interaction is a rare occurrence. SAGE Publications 2020-11-19 /pmc/articles/PMC7686620/ /pubmed/33213238 http://dx.doi.org/10.1177/0300060520969579 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Lin, Chao
Chen, Guohua
Huang, Junbin
Cheng, Yucai
Xu, Yahong
Zhang, Airun
Xue, Hongman
Chen, Chun
Posaconazole aggravates vincristine-related hypertension in children with acute lymphoblastic leukemia: a case report
title Posaconazole aggravates vincristine-related hypertension in children with acute lymphoblastic leukemia: a case report
title_full Posaconazole aggravates vincristine-related hypertension in children with acute lymphoblastic leukemia: a case report
title_fullStr Posaconazole aggravates vincristine-related hypertension in children with acute lymphoblastic leukemia: a case report
title_full_unstemmed Posaconazole aggravates vincristine-related hypertension in children with acute lymphoblastic leukemia: a case report
title_short Posaconazole aggravates vincristine-related hypertension in children with acute lymphoblastic leukemia: a case report
title_sort posaconazole aggravates vincristine-related hypertension in children with acute lymphoblastic leukemia: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686620/
https://www.ncbi.nlm.nih.gov/pubmed/33213238
http://dx.doi.org/10.1177/0300060520969579
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