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Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling embryonic and organ development, as well as cancer progression. Genome-wide sequencing and gene expression profile analyses have demonstrated that Wnt signaling is involved mainly in the processes of brea...

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Autores principales: Xu, Xiufang, Zhang, Miaofeng, Xu, Faying, Jiang, Shaojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686704/
https://www.ncbi.nlm.nih.gov/pubmed/33234169
http://dx.doi.org/10.1186/s12943-020-01276-5
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author Xu, Xiufang
Zhang, Miaofeng
Xu, Faying
Jiang, Shaojie
author_facet Xu, Xiufang
Zhang, Miaofeng
Xu, Faying
Jiang, Shaojie
author_sort Xu, Xiufang
collection PubMed
description Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling embryonic and organ development, as well as cancer progression. Genome-wide sequencing and gene expression profile analyses have demonstrated that Wnt signaling is involved mainly in the processes of breast cancer proliferation and metastasis. The most recent studies have indicated that Wnt signaling is also crucial in breast cancer immune microenvironment regulation, stemness maintenance, therapeutic resistance, phenotype shaping, etc. Wnt/β-Catenin, Wnt–planar cell polarity (PCP), and Wnt–Ca(2+) signaling are three well-established Wnt signaling pathways that share overlapping components and play different roles in breast cancer progression. In this review, we summarize the main findings concerning the relationship between Wnt signaling and breast cancer and provide an overview of existing mechanisms, challenges, and potential opportunities for advancing the therapy and diagnosis of breast cancer.
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spelling pubmed-76867042020-11-25 Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities Xu, Xiufang Zhang, Miaofeng Xu, Faying Jiang, Shaojie Mol Cancer Review Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling embryonic and organ development, as well as cancer progression. Genome-wide sequencing and gene expression profile analyses have demonstrated that Wnt signaling is involved mainly in the processes of breast cancer proliferation and metastasis. The most recent studies have indicated that Wnt signaling is also crucial in breast cancer immune microenvironment regulation, stemness maintenance, therapeutic resistance, phenotype shaping, etc. Wnt/β-Catenin, Wnt–planar cell polarity (PCP), and Wnt–Ca(2+) signaling are three well-established Wnt signaling pathways that share overlapping components and play different roles in breast cancer progression. In this review, we summarize the main findings concerning the relationship between Wnt signaling and breast cancer and provide an overview of existing mechanisms, challenges, and potential opportunities for advancing the therapy and diagnosis of breast cancer. BioMed Central 2020-11-24 /pmc/articles/PMC7686704/ /pubmed/33234169 http://dx.doi.org/10.1186/s12943-020-01276-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Xu, Xiufang
Zhang, Miaofeng
Xu, Faying
Jiang, Shaojie
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
title Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
title_full Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
title_fullStr Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
title_full_unstemmed Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
title_short Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
title_sort wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686704/
https://www.ncbi.nlm.nih.gov/pubmed/33234169
http://dx.doi.org/10.1186/s12943-020-01276-5
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