Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches

Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune impairments and hematopoietic disorders. Understanding how such changes are initiated and how they progress will help in the...

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Autores principales: Zhang, Lei, Mack, Ryan, Breslin, Peter, Zhang, Jiwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686726/
https://www.ncbi.nlm.nih.gov/pubmed/33228751
http://dx.doi.org/10.1186/s13045-020-00994-z
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author Zhang, Lei
Mack, Ryan
Breslin, Peter
Zhang, Jiwang
author_facet Zhang, Lei
Mack, Ryan
Breslin, Peter
Zhang, Jiwang
author_sort Zhang, Lei
collection PubMed
description Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune impairments and hematopoietic disorders. Understanding how such changes are initiated and how they progress will help in the development of medications that could improve the quality life for the elderly and to treat and possibly prevent aging-related hematopoietic diseases. Here, we review the most recent advances in research into HSC aging and discuss the role of HSC-intrinsic events, as well as those that relate to the aging bone marrow niche microenvironment in the overall processes of HSC aging. In addition, we discuss the potential mechanisms by which HSC aging is regulated.
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spelling pubmed-76867262020-11-25 Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches Zhang, Lei Mack, Ryan Breslin, Peter Zhang, Jiwang J Hematol Oncol Review Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune impairments and hematopoietic disorders. Understanding how such changes are initiated and how they progress will help in the development of medications that could improve the quality life for the elderly and to treat and possibly prevent aging-related hematopoietic diseases. Here, we review the most recent advances in research into HSC aging and discuss the role of HSC-intrinsic events, as well as those that relate to the aging bone marrow niche microenvironment in the overall processes of HSC aging. In addition, we discuss the potential mechanisms by which HSC aging is regulated. BioMed Central 2020-11-23 /pmc/articles/PMC7686726/ /pubmed/33228751 http://dx.doi.org/10.1186/s13045-020-00994-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Lei
Mack, Ryan
Breslin, Peter
Zhang, Jiwang
Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
title Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
title_full Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
title_fullStr Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
title_full_unstemmed Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
title_short Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
title_sort molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686726/
https://www.ncbi.nlm.nih.gov/pubmed/33228751
http://dx.doi.org/10.1186/s13045-020-00994-z
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