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Genome-scale CRISPR screening at high sensitivity with an empirically designed sgRNA library
BACKGROUND: In recent years, large-scale genetic screens using the CRISPR/Cas9 system have emerged as scalable approaches able to interrogate gene function with unprecedented efficiency and specificity in various biological contexts. By this means, functional dependencies on both the protein-coding...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686728/ https://www.ncbi.nlm.nih.gov/pubmed/33228647 http://dx.doi.org/10.1186/s12915-020-00905-1 |