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Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications
BACKGROUND: Previous studies evaluated the association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling publishe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686752/ https://www.ncbi.nlm.nih.gov/pubmed/33228581 http://dx.doi.org/10.1186/s12881-020-01169-w |
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author | Imani, Danyal Eslami, Mohammad Masoud Anani-Sarab, Gholamreza Aliyu, Mansur Razi, Bahman Rezaei, Ramazan |
author_facet | Imani, Danyal Eslami, Mohammad Masoud Anani-Sarab, Gholamreza Aliyu, Mansur Razi, Bahman Rezaei, Ramazan |
author_sort | Imani, Danyal |
collection | PubMed |
description | BACKGROUND: Previous studies evaluated the association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature. METHODS: An exhaustive search in Web of Science, Scopus, and PubMed databases was performed to identify all relevant publications before September 2020, and 24 publications (28 studies) with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran’s Q and the I(2) statistics were used to evaluate the degree of heterogeneity between studies. RESULTS: In the overall study populations, a significant positive association was detected under all genotype models and announced the IL-4 C33T polymorphism as a potential risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 C33T polymorphism and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. Furthermore, the results of subgroup analysis by continent were heterogenous. Accordingly, IL-4 C33T polymorphism was a risk factor in Europeans (all models except heterozygote comparison), Americans (all models except recessive and homozygote comparison) and Asians (just recessive and allelic model). Finally, the ethnicity-specific analysis disclosed a significant association between IL-4 C33T polymorphism and asthma risk in Caucasians (all genotype models except heterozygote comparison), while this association was not significant in African-Americans. CONCLUSIONS: This study suggests that IL-4 C33T polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups. |
format | Online Article Text |
id | pubmed-7686752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76867522020-11-25 Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications Imani, Danyal Eslami, Mohammad Masoud Anani-Sarab, Gholamreza Aliyu, Mansur Razi, Bahman Rezaei, Ramazan BMC Med Genet Research Article BACKGROUND: Previous studies evaluated the association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature. METHODS: An exhaustive search in Web of Science, Scopus, and PubMed databases was performed to identify all relevant publications before September 2020, and 24 publications (28 studies) with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran’s Q and the I(2) statistics were used to evaluate the degree of heterogeneity between studies. RESULTS: In the overall study populations, a significant positive association was detected under all genotype models and announced the IL-4 C33T polymorphism as a potential risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 C33T polymorphism and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. Furthermore, the results of subgroup analysis by continent were heterogenous. Accordingly, IL-4 C33T polymorphism was a risk factor in Europeans (all models except heterozygote comparison), Americans (all models except recessive and homozygote comparison) and Asians (just recessive and allelic model). Finally, the ethnicity-specific analysis disclosed a significant association between IL-4 C33T polymorphism and asthma risk in Caucasians (all genotype models except heterozygote comparison), while this association was not significant in African-Americans. CONCLUSIONS: This study suggests that IL-4 C33T polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups. BioMed Central 2020-11-23 /pmc/articles/PMC7686752/ /pubmed/33228581 http://dx.doi.org/10.1186/s12881-020-01169-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Imani, Danyal Eslami, Mohammad Masoud Anani-Sarab, Gholamreza Aliyu, Mansur Razi, Bahman Rezaei, Ramazan Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications |
title | Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications |
title_full | Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications |
title_fullStr | Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications |
title_full_unstemmed | Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications |
title_short | Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications |
title_sort | interleukin-4 gene polymorphism (c33t) and the risk of the asthma: a meta-analysis based on 24 publications |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686752/ https://www.ncbi.nlm.nih.gov/pubmed/33228581 http://dx.doi.org/10.1186/s12881-020-01169-w |
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