Protein diaphanous homolog 1 (Diaph1) promotes myofibroblastic activation of hepatic stellate cells by regulating Rab5a activity and TGFβ receptor endocytosis

TGFβ induces the differentiation of hepatic stellate cells (HSCs) into tumor-promoting myofibroblasts but underlying mechanisms remain incompletely understood. Because endocytosis of TGFβ receptor II (TβRII), in response to TGFβ stimulation, is a prerequisite for TGF signaling, we investigated the r...

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Detalles Bibliográficos
Autores principales: Liu, Donglian, Fu, Xinhui, Wang, Yuanguo, Wang, Xianghu, Wang, Hua, Wen, Jialing, Kang, Ningling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686927/
https://www.ncbi.nlm.nih.gov/pubmed/32304339
http://dx.doi.org/10.1096/fj.201903033R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686927/
https://www.ncbi.nlm.nih.gov/pubmed/32304339
http://dx.doi.org/10.1096/fj.201903033R

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