Cargando…

GNG5 is an unfavourable independent prognostic indicator of gliomas

Gliomas are the most common primary brain tumours, and glioblastomas (GBMs) are subgrouped into four distinct molecular subtypes. This study aimed to identify the potential gene related to glioma progression. Weighted gene co‐expression network analysis (WGCNA) was used to explore the related gene....

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Biao, Han, Zhen‐Yuan, Wang, Wen‐Juan, Ma, Yan‐Bin, Chu, Sheng‐Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686969/
https://www.ncbi.nlm.nih.gov/pubmed/33000557
http://dx.doi.org/10.1111/jcmm.15923
_version_ 1783613434221297664
author Yang, Biao
Han, Zhen‐Yuan
Wang, Wen‐Juan
Ma, Yan‐Bin
Chu, Sheng‐Hua
author_facet Yang, Biao
Han, Zhen‐Yuan
Wang, Wen‐Juan
Ma, Yan‐Bin
Chu, Sheng‐Hua
author_sort Yang, Biao
collection PubMed
description Gliomas are the most common primary brain tumours, and glioblastomas (GBMs) are subgrouped into four distinct molecular subtypes. This study aimed to identify the potential gene related to glioma progression. Weighted gene co‐expression network analysis (WGCNA) was used to explore the related gene. Correlation, ROC, survival and Cox regression analyses were performed. Blue module was strongly associated with WHO grade (r = .65, P = 1e‐19). GNG5 in gliomas was overexpressed compared with normal samples and associated with clinicopathologic characteristics. GNG5 was frequent in Mesenchymal subtype and lowly expressed in Proneural subtype of GBMs. Survival and Cox regression analyses showed that glioma patients with GNG5 overexpression had shorter survival time, and GNG5 was an independent prognostic indicator of overall survival. Overall, GNG5 expression is closely associated with clinicopathologic characteristics and is an independent prognostic indicator for glioma patients, as well as a promising subtype‐associated biomarker in molecular classification of gliomas.
format Online
Article
Text
id pubmed-7686969
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-76869692020-12-03 GNG5 is an unfavourable independent prognostic indicator of gliomas Yang, Biao Han, Zhen‐Yuan Wang, Wen‐Juan Ma, Yan‐Bin Chu, Sheng‐Hua J Cell Mol Med Short Communications Gliomas are the most common primary brain tumours, and glioblastomas (GBMs) are subgrouped into four distinct molecular subtypes. This study aimed to identify the potential gene related to glioma progression. Weighted gene co‐expression network analysis (WGCNA) was used to explore the related gene. Correlation, ROC, survival and Cox regression analyses were performed. Blue module was strongly associated with WHO grade (r = .65, P = 1e‐19). GNG5 in gliomas was overexpressed compared with normal samples and associated with clinicopathologic characteristics. GNG5 was frequent in Mesenchymal subtype and lowly expressed in Proneural subtype of GBMs. Survival and Cox regression analyses showed that glioma patients with GNG5 overexpression had shorter survival time, and GNG5 was an independent prognostic indicator of overall survival. Overall, GNG5 expression is closely associated with clinicopathologic characteristics and is an independent prognostic indicator for glioma patients, as well as a promising subtype‐associated biomarker in molecular classification of gliomas. John Wiley and Sons Inc. 2020-09-30 2020-11 /pmc/articles/PMC7686969/ /pubmed/33000557 http://dx.doi.org/10.1111/jcmm.15923 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Yang, Biao
Han, Zhen‐Yuan
Wang, Wen‐Juan
Ma, Yan‐Bin
Chu, Sheng‐Hua
GNG5 is an unfavourable independent prognostic indicator of gliomas
title GNG5 is an unfavourable independent prognostic indicator of gliomas
title_full GNG5 is an unfavourable independent prognostic indicator of gliomas
title_fullStr GNG5 is an unfavourable independent prognostic indicator of gliomas
title_full_unstemmed GNG5 is an unfavourable independent prognostic indicator of gliomas
title_short GNG5 is an unfavourable independent prognostic indicator of gliomas
title_sort gng5 is an unfavourable independent prognostic indicator of gliomas
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686969/
https://www.ncbi.nlm.nih.gov/pubmed/33000557
http://dx.doi.org/10.1111/jcmm.15923
work_keys_str_mv AT yangbiao gng5isanunfavourableindependentprognosticindicatorofgliomas
AT hanzhenyuan gng5isanunfavourableindependentprognosticindicatorofgliomas
AT wangwenjuan gng5isanunfavourableindependentprognosticindicatorofgliomas
AT mayanbin gng5isanunfavourableindependentprognosticindicatorofgliomas
AT chushenghua gng5isanunfavourableindependentprognosticindicatorofgliomas