Cargando…
GNG5 is an unfavourable independent prognostic indicator of gliomas
Gliomas are the most common primary brain tumours, and glioblastomas (GBMs) are subgrouped into four distinct molecular subtypes. This study aimed to identify the potential gene related to glioma progression. Weighted gene co‐expression network analysis (WGCNA) was used to explore the related gene....
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686969/ https://www.ncbi.nlm.nih.gov/pubmed/33000557 http://dx.doi.org/10.1111/jcmm.15923 |
_version_ | 1783613434221297664 |
---|---|
author | Yang, Biao Han, Zhen‐Yuan Wang, Wen‐Juan Ma, Yan‐Bin Chu, Sheng‐Hua |
author_facet | Yang, Biao Han, Zhen‐Yuan Wang, Wen‐Juan Ma, Yan‐Bin Chu, Sheng‐Hua |
author_sort | Yang, Biao |
collection | PubMed |
description | Gliomas are the most common primary brain tumours, and glioblastomas (GBMs) are subgrouped into four distinct molecular subtypes. This study aimed to identify the potential gene related to glioma progression. Weighted gene co‐expression network analysis (WGCNA) was used to explore the related gene. Correlation, ROC, survival and Cox regression analyses were performed. Blue module was strongly associated with WHO grade (r = .65, P = 1e‐19). GNG5 in gliomas was overexpressed compared with normal samples and associated with clinicopathologic characteristics. GNG5 was frequent in Mesenchymal subtype and lowly expressed in Proneural subtype of GBMs. Survival and Cox regression analyses showed that glioma patients with GNG5 overexpression had shorter survival time, and GNG5 was an independent prognostic indicator of overall survival. Overall, GNG5 expression is closely associated with clinicopathologic characteristics and is an independent prognostic indicator for glioma patients, as well as a promising subtype‐associated biomarker in molecular classification of gliomas. |
format | Online Article Text |
id | pubmed-7686969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76869692020-12-03 GNG5 is an unfavourable independent prognostic indicator of gliomas Yang, Biao Han, Zhen‐Yuan Wang, Wen‐Juan Ma, Yan‐Bin Chu, Sheng‐Hua J Cell Mol Med Short Communications Gliomas are the most common primary brain tumours, and glioblastomas (GBMs) are subgrouped into four distinct molecular subtypes. This study aimed to identify the potential gene related to glioma progression. Weighted gene co‐expression network analysis (WGCNA) was used to explore the related gene. Correlation, ROC, survival and Cox regression analyses were performed. Blue module was strongly associated with WHO grade (r = .65, P = 1e‐19). GNG5 in gliomas was overexpressed compared with normal samples and associated with clinicopathologic characteristics. GNG5 was frequent in Mesenchymal subtype and lowly expressed in Proneural subtype of GBMs. Survival and Cox regression analyses showed that glioma patients with GNG5 overexpression had shorter survival time, and GNG5 was an independent prognostic indicator of overall survival. Overall, GNG5 expression is closely associated with clinicopathologic characteristics and is an independent prognostic indicator for glioma patients, as well as a promising subtype‐associated biomarker in molecular classification of gliomas. John Wiley and Sons Inc. 2020-09-30 2020-11 /pmc/articles/PMC7686969/ /pubmed/33000557 http://dx.doi.org/10.1111/jcmm.15923 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communications Yang, Biao Han, Zhen‐Yuan Wang, Wen‐Juan Ma, Yan‐Bin Chu, Sheng‐Hua GNG5 is an unfavourable independent prognostic indicator of gliomas |
title | GNG5 is an unfavourable independent prognostic indicator of gliomas |
title_full | GNG5 is an unfavourable independent prognostic indicator of gliomas |
title_fullStr | GNG5 is an unfavourable independent prognostic indicator of gliomas |
title_full_unstemmed | GNG5 is an unfavourable independent prognostic indicator of gliomas |
title_short | GNG5 is an unfavourable independent prognostic indicator of gliomas |
title_sort | gng5 is an unfavourable independent prognostic indicator of gliomas |
topic | Short Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686969/ https://www.ncbi.nlm.nih.gov/pubmed/33000557 http://dx.doi.org/10.1111/jcmm.15923 |
work_keys_str_mv | AT yangbiao gng5isanunfavourableindependentprognosticindicatorofgliomas AT hanzhenyuan gng5isanunfavourableindependentprognosticindicatorofgliomas AT wangwenjuan gng5isanunfavourableindependentprognosticindicatorofgliomas AT mayanbin gng5isanunfavourableindependentprognosticindicatorofgliomas AT chushenghua gng5isanunfavourableindependentprognosticindicatorofgliomas |