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The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis()

Inflammation and the coagulation cascade are considered to be the potential mechanisms of ambient particulate matter (PM) exposure-induced adverse cardiovascular events. Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and fibrinogen are arguably the four most commonl...

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Autores principales: Tang, Hong, Cheng, Zilu, Li, Na, Mao, Shuyuan, Ma, Runxue, He, Haijun, Niu, Zhiping, Chen, Xiaolu, Xiang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Applied Science Publishers 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687019/
https://www.ncbi.nlm.nih.gov/pubmed/33254709
http://dx.doi.org/10.1016/j.envpol.2020.115630
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author Tang, Hong
Cheng, Zilu
Li, Na
Mao, Shuyuan
Ma, Runxue
He, Haijun
Niu, Zhiping
Chen, Xiaolu
Xiang, Hao
author_facet Tang, Hong
Cheng, Zilu
Li, Na
Mao, Shuyuan
Ma, Runxue
He, Haijun
Niu, Zhiping
Chen, Xiaolu
Xiang, Hao
author_sort Tang, Hong
collection PubMed
description Inflammation and the coagulation cascade are considered to be the potential mechanisms of ambient particulate matter (PM) exposure-induced adverse cardiovascular events. Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and fibrinogen are arguably the four most commonly assayed markers to reflect the relationships of PM with inflammation and blood coagulation. This review summarized and quantitatively analyzed the existing studies reporting short- and long-term associations of PM(2.5)(PM with an aerodynamic diameter ≤2.5 μm)/PM(10) (PM with an aerodynamic diameter≤10 μm) with important inflammation and blood coagulation markers (TNF-α, IL-6, IL-8, fibrinogen). We reviewed relevant studies published up to July 2020, using three English databases (PubMed, Web of Science, Embase) and two Chinese databases (Wang-Fang, China National Knowledge Infrastructure). The OHAT tool, with some modification, was applied to evaluate risk of bias. Meta-analyses were conducted with random-effects models for calculating the pooled estimate of markers. To assess the potential effect modifiers and the source of heterogeneity, we conducted subgroup analyses and meta-regression analyses where appropriate. The assessment and correction of publication bias were based on Begg’s and Egger’s test and “trim-and-fill” analysis. We identified 44 eligible studies. For short-term PM exposure, the percent change of a 10 μg/m(3) PM(2.5) increase on TNF-α and fibrinogen was 3.51% (95% confidence interval (CI): 1.21%, 5.81%) and 0.54% (95% confidence interval (CI): 0.21%, 0.86%) respectively. We also found a significant short-term association between PM(10) and fibrinogen (percent change = 0.17%, 95% CI: 0.04%, 0.29%). Overall analysis showed that long-term associations of fibrinogen with PM(2.5) and PM(10) were not significant. Subgroup analysis showed that long-term associations of fibrinogen with PM(2.5) and PM(10) were significant only found in studies conducted in Asia. Our findings support significant short-term associations of PM with TNF-α and fibrinogen. Future epidemiological studies should address the role long-term PM exposure plays in inflammation and blood coagulation markers level change.
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spelling pubmed-76870192020-12-07 The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis() Tang, Hong Cheng, Zilu Li, Na Mao, Shuyuan Ma, Runxue He, Haijun Niu, Zhiping Chen, Xiaolu Xiang, Hao Environ Pollut Review Inflammation and the coagulation cascade are considered to be the potential mechanisms of ambient particulate matter (PM) exposure-induced adverse cardiovascular events. Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and fibrinogen are arguably the four most commonly assayed markers to reflect the relationships of PM with inflammation and blood coagulation. This review summarized and quantitatively analyzed the existing studies reporting short- and long-term associations of PM(2.5)(PM with an aerodynamic diameter ≤2.5 μm)/PM(10) (PM with an aerodynamic diameter≤10 μm) with important inflammation and blood coagulation markers (TNF-α, IL-6, IL-8, fibrinogen). We reviewed relevant studies published up to July 2020, using three English databases (PubMed, Web of Science, Embase) and two Chinese databases (Wang-Fang, China National Knowledge Infrastructure). The OHAT tool, with some modification, was applied to evaluate risk of bias. Meta-analyses were conducted with random-effects models for calculating the pooled estimate of markers. To assess the potential effect modifiers and the source of heterogeneity, we conducted subgroup analyses and meta-regression analyses where appropriate. The assessment and correction of publication bias were based on Begg’s and Egger’s test and “trim-and-fill” analysis. We identified 44 eligible studies. For short-term PM exposure, the percent change of a 10 μg/m(3) PM(2.5) increase on TNF-α and fibrinogen was 3.51% (95% confidence interval (CI): 1.21%, 5.81%) and 0.54% (95% confidence interval (CI): 0.21%, 0.86%) respectively. We also found a significant short-term association between PM(10) and fibrinogen (percent change = 0.17%, 95% CI: 0.04%, 0.29%). Overall analysis showed that long-term associations of fibrinogen with PM(2.5) and PM(10) were not significant. Subgroup analysis showed that long-term associations of fibrinogen with PM(2.5) and PM(10) were significant only found in studies conducted in Asia. Our findings support significant short-term associations of PM with TNF-α and fibrinogen. Future epidemiological studies should address the role long-term PM exposure plays in inflammation and blood coagulation markers level change. Elsevier Applied Science Publishers 2020-12 /pmc/articles/PMC7687019/ /pubmed/33254709 http://dx.doi.org/10.1016/j.envpol.2020.115630 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tang, Hong
Cheng, Zilu
Li, Na
Mao, Shuyuan
Ma, Runxue
He, Haijun
Niu, Zhiping
Chen, Xiaolu
Xiang, Hao
The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis()
title The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis()
title_full The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis()
title_fullStr The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis()
title_full_unstemmed The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis()
title_short The short- and long-term associations of particulate matter with inflammation and blood coagulation markers: A meta-analysis()
title_sort short- and long-term associations of particulate matter with inflammation and blood coagulation markers: a meta-analysis()
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687019/
https://www.ncbi.nlm.nih.gov/pubmed/33254709
http://dx.doi.org/10.1016/j.envpol.2020.115630
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