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Basal Histamine H(4) Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif

Histamine H(4) receptor (H(4)R) orthologues are G‐protein‐coupled receptors (GPCRs) that exhibit species‐dependent basal activity. In contrast to the basally inactive mouse H(4)R (mH(4)R), human H(4)R (hH(4)R) shows a high degree of basal activity. We have performed long‐timescale molecular dynamics...

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Detalles Bibliográficos
Autores principales:	Wifling, David, Pfleger, Christopher, Kaindl, Jonas, Ibrahim, Passainte, Kling, Ralf C., Buschauer, Armin, Gohlke, Holger, Clark, Timothy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687114/ https://www.ncbi.nlm.nih.gov/pubmed/31498478 http://dx.doi.org/10.1002/chem.201902801

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